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This has led to research into new formulations with lower environmental problems. One of the most promising alternatives to the use of classical pesticides is the induction of natural plant defences. New formulations based on Cu complexed with heptagluconic acid induce plant innate defences and could be an alternative to classical treatments based on inorganic Cu against bacterial speck. To study the efficacy of this compound in tomato against <jats:italic>P. syringae<\/jats:italic>, we tested its systemic effect Applying the treatments via radicular.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Treated plants showed less infection development and lower number of viable bacteria in leaves. We also observed better performance of parameters involved in plant resistance such as the antioxidant response and the accumulation of phenolic compounds.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>Results showed that soil drench applications can be highly effective for the prevention and control of bacterial speck in tomato plants, showing a reduction in symptoms of \u223c 50%. Moreover, application of Cu heptagluconate induced accumulation of the plant polyphenols caffeic and chlorogenic acids, and reduced the amount of reactive oxygen species in infected plants. \u00a9 2018 Society of Chemical Industry<\/jats:p><\/jats:sec>","DOI":"10.1002\/ps.5050","type":"journal-article","created":{"date-parts":[[2018,4,24]],"date-time":"2018-04-24T05:00:13Z","timestamp":1524546013000},"page":"2601-2607","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Elucidating the mechanism of action of copper heptagluconate on the plant immune system against <i>Pseudomonas syringae<\/i> in tomato (<scp><i>Solanum lycopersicum<\/i><\/scp> L)"],"prefix":"10.1002","volume":"74","author":[{"given":"Ana I","family":"Gonz\u00e1lez\u2010Hern\u00e1ndez","sequence":"first","affiliation":[{"name":"Grupo de Bioqu\u00edmica y Biotecnolog\u00eda, Departamento de Ciencias Agrarias y del Medio Natural Universitat Jaume I de Castell\u00f3n  de la Plana Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1931-1071","authenticated-orcid":false,"given":"Eugenio","family":"Llorens","sequence":"additional","affiliation":[{"name":"Grupo de Bioqu\u00edmica y Biotecnolog\u00eda, Departamento de Ciencias Agrarias y del Medio Natural Universitat Jaume I de Castell\u00f3n  de la Plana Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1709-1140","authenticated-orcid":false,"given":"Carlos","family":"Agust\u00ed\u2010Brisach","sequence":"additional","affiliation":[{"name":"Grupo Patolog\u00eda Agroforestal, Departamento de Agronom\u00eda, ETSIAM Universidad de C\u00f3rdoba  C\u00f3rdoba Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Begonya","family":"Vicedo","sequence":"additional","affiliation":[{"name":"Grupo de Bioqu\u00edmica y Biotecnolog\u00eda, Departamento de Ciencias Agrarias y del Medio Natural Universitat Jaume I de Castell\u00f3n  de la Plana Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Yuste","sequence":"additional","affiliation":[{"name":"Departamento I+D+i IDAI Nature S.L.  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