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Contextually, BCAs may be inhibited by beneficial insect symbionts, which can become potential barriers to entomopathogen\u2010dependent pest biocontrol. Using the symbioses formed by one devastating dipteran pest, <jats:styled-content style=\"fixed-case\"><jats:italic>Delia antiqua<\/jats:italic><\/jats:styled-content>, and its associated microbes as a model system, we sought to determine whether the antagonistic interaction between BCAs and microbial symbionts could affect the outcome of entomopathogen\u2010dependent pest biocontrol.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>The result showed that in contrast to non\u2010axenic <jats:styled-content style=\"fixed-case\"><jats:italic>D. antiqua<\/jats:italic><\/jats:styled-content> larvae, i.e., onion maggots, axenic larvae lost resistance to the entomopathogenic <jats:italic>Beauveria bassiana<\/jats:italic>, and the re\u2010inoculation of microbiota increased the resistance of axenic larvae to <jats:italic>B. bassiana<\/jats:italic>. Furthermore, bacteria frequently isolated from larvae, including <jats:italic>Citrobacter freundii<\/jats:italic>, <jats:italic>Enterobacter ludwigii<\/jats:italic>, <jats:italic>Pseudomonas protegens<\/jats:italic>, <jats:italic>Serratia plymuthica<\/jats:italic>, <jats:italic>Sphingobacterium faecium<\/jats:italic> and <jats:italic>Stenotrophomonas maltophilia<\/jats:italic>, suppressed <jats:italic>B. bassiana<\/jats:italic> conidia germination and hyphal growth, and the re\u2010inoculation of specific individual bacteria enhanced the resistance of axenic larvae to <jats:italic>B. bassiana<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>Bacteria associated with larvae, including <jats:italic>C. freundii<\/jats:italic>, <jats:styled-content style=\"fixed-case\"><jats:italic>E. ludwigii<\/jats:italic><\/jats:styled-content>, <jats:italic>P. protegens<\/jats:italic>, <jats:italic>S. plymuthica<\/jats:italic>, <jats:italic>S. faecium<\/jats:italic> and <jats:styled-content style=\"fixed-case\"><jats:italic>S. maltophilia<\/jats:italic><\/jats:styled-content>, can inhibit <jats:italic>B. bassiana<\/jats:italic> infection. Removing the microbiota can suppress larval resistance to fungal infection. \u00a9 2018 Society of Chemical Industry<\/jats:p><\/jats:sec>","DOI":"10.1002\/ps.5084","type":"journal-article","created":{"date-parts":[[2018,5,24]],"date-time":"2018-05-24T01:10:30Z","timestamp":1527124230000},"page":"170-179","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":46,"title":["Repressed <i>Beauveria bassiana<\/i> infections in <scp><i>Delia antiqua<\/i><\/scp> due to associated microbiota"],"prefix":"10.1002","volume":"75","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7603-2303","authenticated-orcid":false,"given":"Fangyuan","family":"Zhou","sequence":"first","affiliation":[{"name":"Shandong Provincial Key Laboratory of Applied Microbiology Ecology Institute, Qilu University of Technology (Shandong Academy of Sciences)  Jinan 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