{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T06:42:56Z","timestamp":1785825776895,"version":"3.56.0"},"reference-count":32,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,9,5]],"date-time":"2018-09-05T00:00:00Z","timestamp":1536105600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005671","name":"Funda\u00e7\u00e3o de Apoio \u00e0 Pesquisa e \u00e0 Inova\u00e7\u00e3o Tecnol\u00f3gica do Estado de Sergipe","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005671","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pest Management Science"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>One of the most efficient ways to prevent arboviruses, such as dengue fever, yellow fever, chikungunya and Zika, is by controlling their vector, the <jats:italic>Aedes aegypti<\/jats:italic>. Because this vector is becoming resistant to most larvicides used, the development of new larvicides should be considered. \u03b2\u2010Cyclodextrin (\u03b2\u2010CD) complexes have been investigated as an interesting way of enabling the use of essential oils in water as larvicides. This study comprised the development of <jats:italic>Lippia gracilis<\/jats:italic> essential oil (LGEO) and \u03b2\u2010CD inclusion complexes for control of <jats:italic>Ae. aegypti<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Thermal analysis clearly showed the formation of complexes using kneading and co\u2010evaporation methods. Gas chromatography analysis showed that kneading without co\u2010solvent (KW) gave the highest content (\u223c\u00a015%) of the LGEO major component. Moreover, KW showed that the complex had a 50% lethal concentration (LC<jats:sub>50<\/jats:sub>; 33\u2009ppm) lower than that of pure LGEO (39\u2009ppm); in other words, complexing LGEO with \u03b2\u2010CD improved the larvicidal activity. In addition, LGEO complexed with \u03b2\u2010CD (KW) was not harmful to non\u2010target organisms at the concentrations needed to control <jats:italic>Ae. aegypti<\/jats:italic> larvae.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>The inclusion complex with LGEO was a feasible formulation, being economically viable, easy\u2010to\u2010apply and without impact on non\u2010target organisms and, therefore, is a potential alternative larvicide for <jats:italic>Ae. aegypti<\/jats:italic> control. \u00a9 2018 Society of Chemical Industry<\/jats:p><\/jats:sec>","DOI":"10.1002\/ps.5138","type":"journal-article","created":{"date-parts":[[2018,7,12]],"date-time":"2018-07-12T04:05:07Z","timestamp":1531368307000},"page":"452-459","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["<i>Lippia gracilis<\/i> essential oil in \u03b2\u2010cyclodextrin inclusion complexes: an environmentally safe formulation 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