{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T17:56:13Z","timestamp":1778954173410,"version":"3.51.4"},"reference-count":31,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,10,3]],"date-time":"2018-10-03T00:00:00Z","timestamp":1538524800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100010079","name":"Conseil R\u00e9gional de Picardie","doi-asserted-by":"publisher","award":["biopom\u2010GA"],"award-info":[{"award-number":["biopom\u2010GA"]}],"id":[{"id":"10.13039\/501100010079","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004794","name":"Centre National de la Recherche Scientifique","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004794","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004562","name":"Minist\u00e8re de l'Education Nationale, de l'Enseignement Superieur et de la Recherche","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004562","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pest Management Science"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Potato (<jats:styled-content style=\"fixed-case\"><jats:italic>Solanum tuberosum<\/jats:italic><\/jats:styled-content>) is the fourth culture in the world and is widely used in the agri\u2010food industries. They generate by\u2010products in which \u03b1\u2010chaconine and \u03b1\u2010solanine, the two major solanidine\u2010based glycoalkaloids of potato, are present. As secondary metabolites, they play an important role in the protection system of potato and are involved in plant protection against insects. To add value to these by\u2010products, we described here new glycoalkaloids that could have phytosanitary properties.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Solanidine, as a renewable source, was modified with an azido linker and coupled by copper\u2010catalyzed alkyne azide cycloaddition to alkynyl derivatives of the monosaccharides found in the natural potato glycoalkakoids: <jats:sc>D<\/jats:sc>\u2010glucose, <jats:sc>D<\/jats:sc>\u2010galactose and L\u2010rhamnose. The efficacy of our compounds was evaluated on the potato aphid <jats:styled-content style=\"fixed-case\"><jats:italic>Macrosiphum euphorbiae<\/jats:italic><\/jats:styled-content>. The synthetic compounds have stronger aphicidal properties against nymphs than unmodified solanidine. They also showed strong aphicidal activities on adults and a negative impact on fecundity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our synthetic neoglycoalkaloids affected <jats:styled-content style=\"fixed-case\"><jats:italic>Macrosiphum euphorbiae<\/jats:italic><\/jats:styled-content> survival at the nymphal stage as well as at the adult stage. Furthermore, they induced a decrease in fecundity. Our results show that chemical modifications of by\u2010products may afford new sustainable compounds for crop and plant protection. \u00a9 2018 Society of Chemical Industry<\/jats:p><\/jats:sec>","DOI":"10.1002\/ps.5180","type":"journal-article","created":{"date-parts":[[2018,8,23]],"date-time":"2018-08-23T01:28:31Z","timestamp":1534987711000},"page":"793-800","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Synthesis and insecticidal activities of novel solanidine derivatives"],"prefix":"10.1002","volume":"75","author":[{"given":"R\u00e9mi","family":"Beaulieu","sequence":"first","affiliation":[{"name":"Laboratoire de Glycochimie, des Antimicrobiens et des Agroressources (LG2A) CNRS UMR 7378, and Institut de Chimie de Picardie FR 3085, Universit\u00e9 de Picardie \u2013 Jules Verne  Amiens France"},{"name":"Semences, Innovation, Protection, Recherche et Environnement (SIPRE), rue des Champs Potez  Achicourt France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric","family":"Grand","sequence":"additional","affiliation":[{"name":"Laboratoire de Glycochimie, des Antimicrobiens et des Agroressources (LG2A) CNRS UMR 7378, and Institut de Chimie de Picardie FR 3085, Universit\u00e9 de Picardie \u2013 Jules Verne  Amiens France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Imane","family":"Stasik","sequence":"additional","affiliation":[{"name":"Laboratoire de Glycochimie, des Antimicrobiens et des Agroressources (LG2A) CNRS UMR 7378, and Institut de Chimie de Picardie FR 3085, Universit\u00e9 de Picardie \u2013 Jules Verne  Amiens France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacques","family":"Attoumbr\u00e9","sequence":"additional","affiliation":[{"name":"Semences, Innovation, Protection, Recherche et Environnement (SIPRE), rue des Champs Potez  Achicourt France"},{"name":"Ecologie et Dynamique des Syst\u00e8mes Anthropis\u00e9s (EDYSAN) CNRS UMR 7058, Universit\u00e9 de Picardie Jules Verne  Amiens France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Quentin","family":"Chesnais","sequence":"additional","affiliation":[{"name":"Ecologie et Dynamique des Syst\u00e8mes Anthropis\u00e9s (EDYSAN) CNRS UMR 7058, Universit\u00e9 de Picardie Jules Verne  Amiens France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Virginie","family":"Gobert","sequence":"additional","affiliation":[{"name":"Semences, Innovation, Protection, Recherche et Environnement (SIPRE), rue des Champs Potez  Achicourt France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arnaud","family":"Ameline","sequence":"additional","affiliation":[{"name":"Ecologie et Dynamique des Syst\u00e8mes Anthropis\u00e9s (EDYSAN) CNRS UMR 7058, Universit\u00e9 de Picardie Jules Verne  Amiens France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe","family":"Giordanengo","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Picardie Jules Verne, Amiens, France \u2013 Institut Sophia Agrobiotech, CNRS 7254 \u2013 INRA 1355 \u2013 Universit\u00e9 de Nice Sophia Antipolis  Sophia Antipolis France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6398-2721","authenticated-orcid":false,"given":"Jos\u00e9","family":"Kovensky","sequence":"additional","affiliation":[{"name":"Laboratoire de Glycochimie, des Antimicrobiens et des Agroressources (LG2A) CNRS UMR 7378, and Institut de Chimie de Picardie FR 3085, Universit\u00e9 de Picardie \u2013 Jules Verne  Amiens 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