{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T05:29:36Z","timestamp":1780723776675,"version":"3.54.1"},"reference-count":32,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,10,17]],"date-time":"2018-10-17T00:00:00Z","timestamp":1539734400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31870770"],"award-info":[{"award-number":["31870770"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31271135"],"award-info":[{"award-number":["31271135"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pest Management Science"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Latrodectus<\/jats:italic> species are among the most venomous of spiders, with abundant toxic proteinaceous components in their venomous glands and other tissues, as well as their eggs. To date, several proteinaceous toxins with insecticidal potential, including \u03b1\u2010insectotoxin and \u03b4\u2010insectotoxin, two of the most potent known insecticidal toxins, have been purified and characterized by comprehensively utilizing conventional biochemical techniques. This has greatly enhanced our knowledge of the molecular basis and mechanism of action of their toxicity. Application of proteomic and transcriptomic techniques further revealed the synergistic action of multiple <jats:italic>Latrodectus<\/jats:italic> proteinaceous toxins and toxin\u2010like components. Insecticidal toxins from <jats:italic>Latrodectus<\/jats:italic> spiders have great potential in insect pest control; however, more studies are needed to further reveal their mechanisms of action and understand their structures and properties before any practical application, for example, the insecticidal toxin\u2010containing fusion proteins with oral activity. Here, we review current knowledge of the molecular basis and mechanism of action underlying the insecticidal activity of venoms and toxins from <jats:italic>Latrodectus<\/jats:italic> spiders, and examine their potential application in insect pest control. \u00a9 2018 Society of Chemical Industry\n<\/jats:p>","DOI":"10.1002\/ps.5206","type":"journal-article","created":{"date-parts":[[2018,9,11]],"date-time":"2018-09-11T17:18:38Z","timestamp":1536686318000},"page":"318-323","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Molecular basis and mechanism underlying the insecticidal activity of venoms and toxins from <i>Latrodectus<\/i> spiders"],"prefix":"10.1002","volume":"75","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2947-2741","authenticated-orcid":false,"given":"Xianchun","family":"Wang","sequence":"first","affiliation":[{"name":"Key Laboratory of Protein Chemistry and Developmental Biology of Ministry of Education, College of Life Sciences Hunan Normal University  Changsha People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaochao","family":"Tang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Protein Chemistry and Developmental Biology of Ministry of Education, College of Life Sciences Hunan Normal University  Changsha People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dehong","family":"Xu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Protein Chemistry and Developmental Biology of Ministry of Education, College of Life Sciences Hunan Normal University  Changsha People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dianmei","family":"Yu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Protein Chemistry and Developmental Biology of Ministry of Education, College of Life Sciences Hunan Normal University  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