{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T04:47:37Z","timestamp":1792212457387,"version":"4.4.0"},"reference-count":62,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2019,3,10]],"date-time":"2019-03-10T00:00:00Z","timestamp":1552176000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pest Management Science"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>With the anticipated population growth in the coming decades, the changing regulatory environment, and the continued emergence of resistance to commercial pesticides, there is a constant need to discover new lead chemistries with novel modes of action. We have established a portfolio of approaches to accelerate lead generation. One of these approaches capitalizes on the rich bioactivity of natural products (NPs), highlighted by the numerous examples of NP\u2010based crop protection compounds. Within Corteva Agriscience and the affiliated preceding companies, NPs have been a fruitful approach, for nearly three decades, to identifying and bringing to the market crop protection products inspired by or originating from NPs, . Included in these NP\u2010based crop protection products are the spinosyns family of insecticides, and those from more recent areas of NP\u2010based fungicidal chemistry, as highlighted in this perspective. \u00a9 2019 Society of Chemical Industry<\/jats:p>","DOI":"10.1002\/ps.5350","type":"journal-article","created":{"date-parts":[[2019,1,24]],"date-time":"2019-01-24T04:15:35Z","timestamp":1548303335000},"page":"2301-2309","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":94,"title":["Natural products: a strategic lead generation approach in crop protection discovery"],"prefix":"10.1002","volume":"75","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1060-904X","authenticated-orcid":false,"given":"Beth A","family":"Lorsbach","sequence":"first","affiliation":[{"name":"Corteva Agriscience\u2122, Agriculture Division of DowDuPont\u2122 Crop Protection Discovery, Dow AgroSciences  Indianapolis IN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0526-7594","authenticated-orcid":false,"given":"Thomas C","family":"Sparks","sequence":"additional","affiliation":[{"name":"Corteva Agriscience\u2122, Agriculture Division of DowDuPont\u2122 Crop Protection Discovery, Dow AgroSciences  Indianapolis IN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert M","family":"Cicchillo","sequence":"additional","affiliation":[{"name":"Corteva Agriscience\u2122, Agriculture Division of DowDuPont\u2122 Crop Protection Discovery, Dow AgroSciences  Indianapolis IN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Negar V","family":"Garizi","sequence":"additional","affiliation":[{"name":"Corteva Agriscience\u2122, Agriculture Division of DowDuPont\u2122 Crop Protection Discovery, Dow AgroSciences  Indianapolis IN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald R","family":"Hahn","sequence":"additional","affiliation":[{"name":"Corteva Agriscience\u2122, Agriculture Division of DowDuPont\u2122 Crop Protection Discovery, Dow AgroSciences  Indianapolis IN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin G","family":"Meyer","sequence":"additional","affiliation":[{"name":"Corteva Agriscience\u2122, Agriculture Division of DowDuPont\u2122 Crop Protection Discovery, Dow AgroSciences  Indianapolis IN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,3,10]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2015.01.009"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jnatprod.5b01055"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2009.01.046"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/np300024u"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ps.3744"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ps.4458"},{"key":"e_1_2_10_8_1","unstructured":"Agranova Alliance Crop Protection Actives. Available:http:\/\/www.agranova.co.uk[20 September 2018]."},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpa.2004.04.011"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2007.04.001"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1168243"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/np100550t"},{"key":"e_1_2_10_13_1","first-page":"1","article-title":"The U.S. culture collection network responding to the requirements of the Nagoya Protocol on access and benefit sharing","volume":"8","author":"McKluskey K","year":"2017","journal-title":"MBio"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1021\/bk-2015-1204.ch001"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/ps.4457"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1614680114"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/ps.2780390206"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf60227a012"},{"key":"e_1_2_10_19_1","first-page":"35","article-title":"Lead generation: designing the right approach","volume":"295","author":"Morrod RS","year":"1981","journal-title":"Phil Trans R Soc London B"},{"key":"e_1_2_10_20_1","first-page":"615","article-title":"Insecticides and their design","volume":"15","author":"Hummel HE","year":"1983","journal-title":"J Nematol"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pestbp.2013.05.012"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/ps.4336"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1021\/bk-2017-1264.ch001"},{"key":"e_1_2_10_24_1","first-page":"41","volume-title":"R&D Expenditure in 2014 and Expectations for 2019","author":"Phillips M","year":"2016"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/1526-4998(200008)56:8<696::AID-PS182>3.0.CO;2-5"},{"key":"e_1_2_10_26_1","first-page":"281","article-title":"Ilotycin, a new antibiotic","volume":"2","author":"McGuire JM","year":"1952","journal-title":"Antibiot Chemother"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1159\/000386635"},{"key":"e_1_2_10_28_1","first-page":"606","article-title":"Vancomycin, a new antibiotic. I. chemical and biologic properties","volume":"3","author":"McCormick MH","year":"1956","journal-title":"Antibiot Ann"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja00876a034"},{"key":"e_1_2_10_30_1","first-page":"320","article-title":"Tylosin, a new antibiotic: I. microbiological studies","volume":"11","author":"McGuire JM","year":"1961","journal-title":"Antibiot Chemother"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10822-008-9205-8"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2009.02.035"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1021\/np0602517"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/ps.4588"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/ps.4743"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-22894-6"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/ps.5217"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/ps.5037"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.8b03484"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf052585s"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/ps.1579"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1080\/13880200902988629"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10886-013-0238-7"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1021\/np5008153"},{"key":"e_1_2_10_45_1","first-page":"10","article-title":"Alveolaride A\u2010C three antifungal peptides from Microascus alveolaris and their biological activities","volume":"18","author":"Fotso S","year":"2017","journal-title":"J Nat Prod"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1039\/b817069j"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1039\/C6NP00024J"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/ja.2009.11"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10295-016-1782-2"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.7164\/antibiotics.49.1226"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.7164\/antibiotics.49.639"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.7164\/antibiotics.51.1113"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4039(98)00796-5"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2005.02.065"},{"key":"e_1_2_10_55_1","unstructured":"MeyerKG OwenWJ NiyazNM RogersRB FitzpatrickGM LiF NugentJ RicksMJ SlanecTJ YaoC Structure\u2010activity relationship studies on the natural product UK\u20102A.Proceedings of the 252nd National ACS meeting AGRO197. (2016)."},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fgb.2015.04.010"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1002\/ps.5130"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.11.031"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200601297"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.2174\/1568026616666151012111209"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fgb.2016.01.006"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.1659"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature12051"}],"container-title":["Pest Management Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fps.5350","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ps.5350","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ps.5350","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/scijournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ps.5350","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T10:00:06Z","timestamp":1761040806000},"score":1,"resource":{"primary":{"URL":"https:\/\/scijournals.onlinelibrary.wiley.com\/doi\/10.1002\/ps.5350"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3,10]]},"references-count":62,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2019,9]]}},"alternative-id":["10.1002\/ps.5350"],"URL":"https:\/\/doi.org\/10.1002\/ps.5350","archive":["Portico"],"relation":{},"ISSN":["1526-498X","1526-4998"],"issn-type":[{"value":"1526-498X","type":"print"},{"value":"1526-4998","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,3,10]]},"assertion":[{"value":"2018-11-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-01-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-03-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}