{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T14:10:26Z","timestamp":1784902226100,"version":"3.55.0"},"reference-count":35,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,9,5]],"date-time":"2019-09-05T00:00:00Z","timestamp":1567641600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Basic Research Program of China","doi-asserted-by":"publisher","award":["2017YFD0200506"],"award-info":[{"award-number":["2017YFD0200506"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pest Management Science"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Myricetin and sulfonamide derivatives exhibited a wide variety of biological activity. In order to develop highly bioactive molecules, novel myricetin derivatives containing sulfonamide moiety were synthesized and antibacterial activities were investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>The results of bioassays indicated that compound <jats:bold>A12<\/jats:bold>, having an EC<jats:sub>50<\/jats:sub> value of 4.7\u00a0\u03bcg\u2009mL<jats:sup>\u22121<\/jats:sup>, exhibited the best <jats:italic>in vitro<\/jats:italic> antibacterial activities against <jats:italic>Xanthomonas oryzae pv. oryzae<\/jats:italic> (<jats:italic>X. oryzae pv. o<\/jats:italic>.); EC<jats:sub>50<\/jats:sub> values for this compound were even better than those of thiodiazole\u2010copper (TC, 71.4\u00a0\u03bcg\u2009mL<jats:sup>\u22121<\/jats:sup>) and bismerthiazol (BT, 54.7\u00a0\u03bcg\u2009mL<jats:sup>\u22121<\/jats:sup>). Compound <jats:bold>A2<\/jats:bold>, having an EC<jats:sub>50<\/jats:sub> value of 1.1\u00a0\u03bcg\u2009mL<jats:sup>\u22121<\/jats:sup>, exhibited the best <jats:italic>in vitro<\/jats:italic> antibacterial activities against <jats:italic>Xanthomonas axonopodis pv. citri<\/jats:italic> (<jats:italic>X. axonopodis pv. c<\/jats:italic>); values were notably better than those of TC (60.0\u00a0\u03bcg\u2009mL<jats:sup>\u22121<\/jats:sup>) and BT (48.9\u00a0\u03bcg\u2009mL<jats:sup>\u22121<\/jats:sup>). Scanning electron microscopy analysis indicated that compounds <jats:bold>A2<\/jats:bold> and <jats:bold>A12<\/jats:bold> caused the cell membranes of <jats:italic>X. axonopodis pv. c<\/jats:italic> and <jats:italic>X. oryzae pv. o<\/jats:italic>. to break or deform, respectively. When the concentration of compound <jats:bold>A12<\/jats:bold> was 100\u2009\u03bcg\u2009mL<jats:sup>\u22121<\/jats:sup>, the effective curative activity against bacterial leaf blight of rice was 44.2% <jats:italic>in vivo<\/jats:italic> and the effective protection activity was 58.2% <jats:italic>in vivo<\/jats:italic>, results that were both better than values for TC (18.9 and 21.4%, respectively) and BT (12.5 and 12.5%, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>Novel myricetin derivatives containing a sulfonamide moiety were synthesized and bioassay results showed that compounds <jats:bold>A2<\/jats:bold> and <jats:bold>A12<\/jats:bold> exhibited the best antibacterial activities. \u00a9 2019 Society of Chemical Industry<\/jats:p><\/jats:sec>","DOI":"10.1002\/ps.5587","type":"journal-article","created":{"date-parts":[[2019,8,16]],"date-time":"2019-08-16T08:57:42Z","timestamp":1565945862000},"page":"853-860","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":73,"title":["Design, synthesis and antibacterial activities against <i>Xanthomonas oryzae pv. oryzae, Xanthomonas axonopodis pv. Citri<\/i> and <i>Ralstonia solanacearum<\/i> of novel myricetin derivatives containing sulfonamide moiety"],"prefix":"10.1002","volume":"76","author":[{"given":"Shichun","family":"Jiang","sequence":"first","affiliation":[{"name":"State Key Laboratory Breeding Base of Green Pesticide and Agricultural Bioengineering, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Research and Development Center for Fine Chemicals Guizhou University  Guiyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Tang","sequence":"additional","affiliation":[{"name":"State Key Laboratory Breeding Base of Green Pesticide and Agricultural Bioengineering, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Research and Development Center for Fine Chemicals Guizhou University  Guiyang 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