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In this context, the employment of compounds isolated from plants is an important issue regarding infection and snail control. The aim of this study was therefore to evaluate the effects of curcumin (CUR), a compound isolated from\n                      <jats:italic>Curcuma longa<\/jats:italic>\n                      , against snails and embryos of\n                      <jats:italic>Biomphalaria glabrata<\/jats:italic>\n                      , which is the most important intermediate host of schistosomiasis in the Americas, as well as in cercariae, the infecting larval stage of\n                      <jats:italic>Schistosoma mansoni<\/jats:italic>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      CUR presented high activity against\n                      <jats:italic>B. glabrata<\/jats:italic>\n                      embryos and moderate activity against newborn and adult snails. The lethal concentration (LC\n                      <jats:sub>50<\/jats:sub>\n                      ) values after being exposed for 24\u2009h and evaluated for 7\u2009days were 6.54 (95% confidence interval (CI) 5.86\u20137.30) \u03bcg\u00a0mL\n                      <jats:sup>\u22121<\/jats:sup>\n                      for the embryos and 42.29 (95% CI 33.82\u201352.87) \u03bcg\u00a0mL\n                      <jats:sup>\u22121<\/jats:sup>\n                      and 87.69 (95% CI 68.82\u2013111.7) \u03bcg\u00a0mL\n                      <jats:sup>\u22121<\/jats:sup>\n                      for the newborn and adult snails, respectively. Moreover, CUR inhibited the development of embryos and egg hatching, and decreased the fecundity rates of adult snails. CUR also demonstrated cercaricidal activity with LC\n                      <jats:sub>50<\/jats:sub>\n                      values lower than 10\u00a0\u03bcg\u00a0mL\n                      <jats:sup>\u22121<\/jats:sup>\n                      at 1, 3, 6, 9 and 12\u2009h, respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>Our data show that CUR has potential molluscicidal and cercaricidal activities. Moreover, as a nutraceutical compound that is toxic to both invertebrate host and parasite, CUR has the potential to be explored as a safe new agent to combat schistosomiasis. \u00a9 2019 Society of Chemical Industry<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ps.5631","type":"journal-article","created":{"date-parts":[[2019,10,6]],"date-time":"2019-10-06T05:08:08Z","timestamp":1570338488000},"page":"1228-1234","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Molluscicidal and cercaricidal activities of curcumin on\n                    <i>Biomphalaria glabrata<\/i>\n                    and\n                    <i>Schistosoma mansoni<\/i>\n                    cercariae"],"prefix":"10.1002","volume":"76","author":[{"given":"Jaqueline L","family":"Matos","sequence":"first","affiliation":[{"name":"Research Group on Natural Products Center for Research in Sciences and Technology, University of Franca  Franca Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen R","family":"da Silva","sequence":"additional","affiliation":[{"name":"Research Group on Natural Products Center for Research in Sciences and Technology, University of Franca  Franca Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucas A","family":"de Lima Paula","sequence":"additional","affiliation":[{"name":"Research Group on Natural Products Center for Research in Sciences and Technology, University of Franca  Franca Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilson R","family":"Cunha","sequence":"additional","affiliation":[{"name":"Research Group on Natural Products Center for Research in Sciences and Technology, University of Franca  Franca Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvador B","family":"Ramos","sequence":"additional","affiliation":[{"name":"Department of Health Promotion University of Franca  Franca Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanderlei","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Immunology, College of Medicine of Ribeir\u00e3o Preto University of S\u00e3o Paulo  Ribeir\u00e3o Preto Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernanda J","family":"Cabral","sequence":"additional","affiliation":[{"name":"Department of Animal Biology Institute of Biology, University of Campinas  Campinas Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lizandra G","family":"Magalh\u00e3es","sequence":"additional","affiliation":[{"name":"Research Group on Natural Products Center for Research in Sciences and Technology, University of Franca  Franca Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,11,8]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-018-0013-8"},{"key":"e_1_2_7_3_1","unstructured":"WHO Schistosomiasis (2019). 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