{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T17:46:52Z","timestamp":1790790412976,"version":"4.1.0"},"reference-count":28,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,2,7]],"date-time":"2020-02-07T00:00:00Z","timestamp":1581033600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000200","name":"United States Agency for International Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000200","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000200","name":"United States Agency for International Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000200","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011893","name":"Pan American Health Organization","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011893","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pest Management Science"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>The re\u2010emergence of worldwide concern with arthropod\u2010borne viruses (arboviruses) draws increasing attention to their mosquito vectors, particularly <jats:styled-content style=\"fixed-case\"><jats:italic>Aedes aegypti<\/jats:italic><\/jats:styled-content>, whose control heavily rely on insecticide use. As a consequence, insecticide resistance is frequent, but the general patterns of occurrence, cross\u2010resistance and prevailing mechanisms remain unrecognized in some areas such as the Neotropical region. Thus, we sought here to recognize the general trends and patterns of insecticide resistance in Latin America and the Caribbean. A systematic literature review (2008\u20132018) aimed the data\u2010gathering for the region and meta\u2010analyses to address the stated knowledge gap.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>A high incidence of insecticide resistance prevails in the mosquito populations of the region. Dichlorodiphenyltrichloroethane (DDT), temephos and deltamethrin were the main insecticides evaluated and the meta\u2010analyses indicate a high frequency of DDT\u2010resistant populations (86.7\u2009\u00b1\u20090.1%), followed by temephos (75.7\u2009\u00b1\u20090.1%) and deltamethrin (33.0\u2009\u00b1\u20090.1%). No evidence of cross\u2010resistance was detected among these three insecticides, and the V1016I knockdown (KDR) site mutation does not explain the patterns of deltamethrin resistance in the region.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>Resistance to DDT, temephos and deltamethrin is serious and widespread, and there is no cross\u2010resistance among them. Altered target site sensitivity is not the main pyrethroid resistance mechanism, which is likely due to a mix of mechanisms. Therefore, the replacement of deltamethrin and particularly temephos in the region by alternative insecticides is an important resistance management recommendation, but should be done with compounds out of the cross\u2010resistance spectrum for these populations and insecticides. Nonetheless, the non\u2010recognition of the prevalent resistance mechanisms in the region makes this suggestion more difficult to apply and invites more broad\u2010scale studies of resistance mechanisms to fill this knowledge gap and improve the resistance management recommendations. \u00a9 2020 Society of Chemical Industry<\/jats:p><\/jats:sec>","DOI":"10.1002\/ps.5752","type":"journal-article","created":{"date-parts":[[2020,1,19]],"date-time":"2020-01-19T23:25:08Z","timestamp":1579476308000},"page":"2144-2157","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Patterns of insecticide resistance in <i>Aedes aegypti<\/i>: meta\u2010analyses of surveys in Latin America and the Caribbean"],"prefix":"10.1002","volume":"76","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6229-7549","authenticated-orcid":false,"given":"Raul Narciso C","family":"Guedes","sequence":"first","affiliation":[{"name":"Departamento de Entomologia Universidade Federal de Vi\u00e7osa  Vi\u00e7osa Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaley","family":"Beins","sequence":"additional","affiliation":[{"name":"Division of Health and Environment Abt Associates  Rockville Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis","family":"Navarro Costa","sequence":"additional","affiliation":[{"name":"Department of Communicable Diseases and Environmental Determinants of Health Neglected, Tropical and Vector\u2010Borne Diseases, Pan\u2010American Health Organization  Washington District of Columbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanini E","family":"Coelho","sequence":"additional","affiliation":[{"name":"Department of Communicable Diseases and Environmental Determinants of Health Neglected, Tropical and Vector\u2010Borne Diseases, Pan\u2010American Health Organization  Washington District of 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