{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T01:07:22Z","timestamp":1792026442176,"version":"4.4.0"},"reference-count":43,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2020,3,24]],"date-time":"2020-03-24T00:00:00Z","timestamp":1585008000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21406274"],"award-info":[{"award-number":["21406274"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31970047\u0141"],"award-info":[{"award-number":["31970047\u0141"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pest Management Science"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Matrine is an important traditional plant\u2010derived insecticide with broad\u2010spectrum activity. However, due to its moderate activity, matrine is mainly applied in combination with other pesticides. In order to discover new potential natural\u2010product\u2010based crop protection agents, a series of matrine derivatives characterized by cyclohexylamine group were synthesized to screen their insecticidal activity against seven typically agricultural pests.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>The structural configurations of compounds were characterized by IR, <jats:sup>1<\/jats:sup>H NMR, <jats:sup>13<\/jats:sup>C NMR, MS and XRD, with the pure yields of 42%, 65% and 71%, respectively. Although all compounds showed poor insecticidal activity against five lepidoptera pests, the compounds 2 and 4 displayed remarkable insecticidal activities against <jats:italic>Lipaphis erysimi<\/jats:italic> and <jats:italic>Mulberry Root\u2010Knot Nematode<\/jats:italic> with a concentration\u2010dependent manner within 0.5~1.5 mg\/ mL. Compared with matrine (60%), compounds 2 and 4 exhibited potent insecticidal activities against <jats:italic>L. erysimi<\/jats:italic>, with a corrected mortality of 83.3% and 89.7%, respectively. They also showed excellent control effects on <jats:italic>Mulberry Root\u2010Knot Nematode<\/jats:italic>, with corrected mortality as high as 88% and 80%, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>All four synthesized matrine derivatives showed poor insecticidal activity against five lepidoptera pests, but the compounds 2 and 4 exhibited much stronger insecticidal activities against <jats:italic>L. erysimi<\/jats:italic> and <jats:italic>Mulberry Root\u2010Knot Nematode<\/jats:italic> than matrine. Combined with the structural characteristics of compounds 1~4, we conclude that 4\u2010methylcyclohexylamine, not the carbon disulfide group or cyclohexylamine group alone, mainly contributed to the improvement of insecticidal activities of matrine derivatives against these two agricultural pests. This work provides a direction and foundation for structural optimization of the matrine pesticides in the future. \u00a9 2020 Society of Chemical Industry<\/jats:p><\/jats:sec>","DOI":"10.1002\/ps.5817","type":"journal-article","created":{"date-parts":[[2020,3,13]],"date-time":"2020-03-13T02:52:36Z","timestamp":1584067956000},"page":"2711-2719","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Semi\u2010synthesis and characterization of some new matrine derivatives as insecticidal agents"],"prefix":"10.1002","volume":"76","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9341-5445","authenticated-orcid":false,"given":"Xingan","family":"Cheng","sequence":"first","affiliation":[{"name":"Institute of Natural Product Chemistry, College of Chemistry and Chemical Engineering, Zhongkai University of Agriculture and Engineering  Guangzhou Guangdong 510225 China"},{"name":"Department of Ocean Science The Hong Kong 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