{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T02:33:55Z","timestamp":1789871635052,"version":"4.0.1"},"reference-count":42,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2020,5,15]],"date-time":"2020-05-15T00:00:00Z","timestamp":1589500800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21672044"],"award-info":[{"award-number":["21672044"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pest Management Science"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>\n                      The rice bacterial leaf blight (BLB) is one of the most serious bacterial diseases caused by\n                      <jats:italic>Xanthomonas oryzae<\/jats:italic>\n                      pv.\n                      <jats:italic>oryzae<\/jats:italic>\n                      (\n                      <jats:italic>Xoo<\/jats:italic>\n                      )\n                      <jats:italic>,<\/jats:italic>\n                      which can cause yield loss of rice up to 50%. The three\u2010dimensional quantitative structure\u2013activity relationship (3D\u2010QSAR) is an important auxiliary method to find potential high\u2010efficient pesticides active structures.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      A series of novel 1,3,4\u2010oxadiazole compounds were designed and synthesized based on the 3D\u2010QSAR model, and their antibacterial activities\n                      <jats:italic>in vitro<\/jats:italic>\n                      against\n                      <jats:italic>Xoo<\/jats:italic>\n                      were evaluated. The results indicated that all the target compounds showed excellent\n                      <jats:italic>in vitro<\/jats:italic>\n                      antibacterial activities. For example, the compounds\n                      <jats:bold>6<\/jats:bold>\n                      ,\n                      <jats:bold>12<\/jats:bold>\n                      ,\n                      <jats:bold>13<\/jats:bold>\n                      ,\n                      <jats:bold>20<\/jats:bold>\n                      ,\n                      <jats:bold>21<\/jats:bold>\n                      , and\n                      <jats:bold>23<\/jats:bold>\n                      exhibited excellent antibacterial activities against\n                      <jats:italic>Xoo<\/jats:italic>\n                      , with half\u2010maximal effective concentration (EC\n                      <jats:sub>50<\/jats:sub>\n                      ) values of 0.24, 0.31, 0.36, 0.29, 0.19, and 0.31\u2009mg\/L, respectively, which were superior to the antibacterial agents thiodiazole copper (127.44\u2009mg\/L) and bismerthiazol (91.08\u2009mg\/L). Meanwhile, compound\n                      <jats:bold>21<\/jats:bold>\n                      showed good antibacterial activity\n                      <jats:italic>in vivo<\/jats:italic>\n                      against BLB, with curative and protective activities of 46.7% and 56.4%, respectively, which were superior to thiodiazole copper (28.5% and 32.5%) and bismerthiazol (37.6% and 38.4%). Compound\n                      <jats:bold>21<\/jats:bold>\n                      can significantly reduce the extracellular polysaccharides production of\n                      <jats:italic>Xoo<\/jats:italic>\n                      , increase the permeability of the cell membranes, and also can cause cell surface wrinkles, deformation and dryness.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>\n                      The 3D\u2010QSAR model can be used to find sulfone compounds containing a 1,3,4\u2010oxadiazole moiety with higher antibacterial activity, and compound\n                      <jats:bold>21<\/jats:bold>\n                      can be used as a potential antibacterial agent in the future. \u00a9 2020 Society of Chemical Industry\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ps.5873","type":"journal-article","created":{"date-parts":[[2020,4,28]],"date-time":"2020-04-28T06:13:36Z","timestamp":1588054416000},"page":"3188-3198","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":62,"title":["Novel sulfone derivatives containing a 1,3,4\u2010oxadiazole moiety: design and synthesis based on the\n                    <scp>3D\u2010QSAR<\/scp>\n                    model as potential antibacterial agent"],"prefix":"10.1002","volume":"76","author":[{"given":"Jixiang","family":"Chen","sequence":"first","affiliation":[{"name":"State Key Laboratory Breeding Base of Green Pesticide and Agricultural Bioengineering, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Research and Development Center for Fine Chemicals Guizhou University  Guiyang 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