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Under the EDSP, 11 Tier 1 assays were run following the USEPA's validated 890\u2010series test guidelines and included five <jats:italic>in vitro<\/jats:italic> and six <jats:italic>in vivo<\/jats:italic> assays to evaluate the EAT pathways. Steroidogenesis was evaluated as part of the estrogen and androgen pathways. An up\u2010to\u2010date critical review has been conducted that considered results from the EDSP Tier 1 battery, guideline regulatory studies and an in\u2010depth analysis of the literature studies that informed an endocrine assessment. A strength of this evaluation was that it included data across multiple levels of biological organization, and mammalian and nonmammalian test systems. There was strong agreement across the <jats:italic>in vitro<\/jats:italic> and <jats:italic>in vivo<\/jats:italic> Tier 1 battery, guideline studies and relevant literature studies, demonstrating that glyphosate does not interact with EAT pathways including steroidogenesis. Based on an analysis of the comprehensive toxicology database for glyphosate and the literature, this review has concluded that glyphosate does not have endocrine\u2010disrupting properties through estrogen, androgen, thyroid and steroidogenic modes of action. \u00a9 2020 Society of Chemical Industry<\/jats:p>","DOI":"10.1002\/ps.5983","type":"journal-article","created":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T07:49:16Z","timestamp":1593589756000},"page":"2886-2906","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Review and analysis of the potential for glyphosate to interact with the estrogen, androgen and thyroid pathways"],"prefix":"10.1002","volume":"76","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5872-2351","authenticated-orcid":false,"given":"Steven L","family":"Levine","sequence":"first","affiliation":[{"name":"Global Regulatory Science Bayer Crop Science  Chesterfield MO USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth G","family":"Webb","sequence":"additional","affiliation":[{"name":"Global Regulatory Science Bayer Crop Science  Chesterfield MO USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David A","family":"Saltmiras","sequence":"additional","affiliation":[{"name":"Global Regulatory Science Bayer Crop Science  Chesterfield MO USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,7,17]]},"reference":[{"key":"e_1_2_7_2_1","volume-title":"Chemically\u2010Induced Alterations in Sexual and Functional Development: The Wildlife\/Human Connection","author":"Colborn T","year":"1992"},{"key":"e_1_2_7_3_1","unstructured":"Weybridge Conference. 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