{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T19:36:05Z","timestamp":1781292965277,"version":"3.54.1"},"reference-count":19,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2020,8,24]],"date-time":"2020-08-24T00:00:00Z","timestamp":1598227200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pest Management Science"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Mosquitoes remain one of the most significant threats to the health of humans throughout the world. This study was designed to evaluate the biting deterrent effects of a series of ester analogs of undecanoic acid (C:11:0) and dodecanoic acid (C:12:0) against <jats:italic>Aedes aegypti<\/jats:italic> (L), (Diptera: Culicidae), the yellow fever mosquito, using Klun and Debboun (K&amp;D) and Ali and Khan (A&amp;K) bioassay systems.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>In the K&amp;D bioassays, C:11:0 esters methyl undecanoate, propyl undecanoate, butyl undecanoate, and pentyl undecanoate, and the C:12:0 esters methyl dodecanoate, ethyl dodecanoate, propyl dodecanoate, octyl dodecanoate, and dodecyl dodecanoate were most active. All of these esters were as effective as <jats:italic>N<\/jats:italic>,<jats:italic>N<\/jats:italic>\u2010diethyl\u2010<jats:italic>m<\/jats:italic>\u2010toluamide (DEET) and as effective as the parent acids undecanoic acid and dodecanoic acid with biting deterrence index values ranging from 0.80 to 0.99. In the <jats:italic>in vitro<\/jats:italic> A&amp;K bioassay undecanoic acid with a minimum effective dose (MED) of 3.125\u2009\u03bcg\u2009cm<jats:sup>\u22122<\/jats:sup> was the most active compound and showed higher activity than DEET (MED of 25\u2009\u03bcg\u2009cm<jats:sup>\u22122<\/jats:sup>). The most active synthetic analog was butyl undecanoate with a MED of 12.5\u00a0\u03bcg\u2009cm<jats:sup>\u22122<\/jats:sup>. The next most active analogs are the methyl ester analogs methyl undecanoate and methyl dodecanoate, both with MED values of 25\u2009\u03bcg\u2009cm<jats:sup>\u22122<\/jats:sup>.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>Fatty acid synthetic esters and structural analogs are a promising source of new mosquito repelling compounds and should be investigated further. Published 2020. This article is a U.S. Government work and is in the public domain in the USA.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ps.5994","type":"journal-article","created":{"date-parts":[[2020,7,10]],"date-time":"2020-07-10T05:50:25Z","timestamp":1594360225000},"page":"3737-3743","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Biting deterrency of undecanoic acid and dodecanoic acid ester analogs against <i>Aedes aegypti<\/i>"],"prefix":"10.1002","volume":"77","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5163-9045","authenticated-orcid":false,"given":"Charles L","family":"Cantrell","sequence":"first","affiliation":[{"name":"Natural Products Utilization Research Unit US Department of Agriculture, Agricultural Research Service  University MS USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed A","family":"Zaki","sequence":"additional","affiliation":[{"name":"Pharmacognosy Department, Faculty of Pharmacy Beni Suef University  Beni Suef Egypt"},{"name":"National Center for Natural Products Research The University of Mississippi  University MS USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amber","family":"Reichley","sequence":"additional","affiliation":[{"name":"Natural Products Utilization Research Unit US Department of Agriculture, Agricultural Research Service  University MS USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matt","family":"Sink","sequence":"additional","affiliation":[{"name":"Natural Products Utilization Research Unit US Department of Agriculture, Agricultural Research Service  University MS USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seong J","family":"Kim","sequence":"additional","affiliation":[{"name":"Natural Products Utilization Research Unit US Department of Agriculture, Agricultural Research Service  University MS USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5182-565X","authenticated-orcid":false,"given":"Abbas","family":"Ali","sequence":"additional","affiliation":[{"name":"National Center for Natural Products Research The University of Mississippi  University MS USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,8,24]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(19)30161-6"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph14020124"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00436-015-4656-z"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.indcrop.2015.06.050"},{"key":"e_1_2_6_6_1","article-title":"Insect repellents: an updated review for the clinician","author":"Quoc\u2010Bao DN","year":"2018","journal-title":"J Am Acad Dermatol"},{"key":"e_1_2_6_7_1","volume-title":"A Global Brief on Vector\u2010Borne Diseases","author":"WHO","year":"2014"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf300101w"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1603\/ME10244"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1603\/ME12026"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1139\/cjm-2018-0131"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf8008662"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.2987\/8756-971X(2005)21[64:ANIVBS]2.0.CO;2"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/jme\/tjx100"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/jmedent\/47.5.924"},{"key":"e_1_2_6_16_1","volume-title":"Chemicals Evaluated as Insecticides and Repellents at Orlando, Fla","author":"US Department of Agriculture","year":"1954"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/ee\/11.1.223"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-17765-5"},{"key":"e_1_2_6_19_1","unstructured":"VandermeerRK BrennerRJ CataldoDA VorisPVandLipinskyES Methods and compositions for attracting or repelling cockroaches. 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