{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T22:18:49Z","timestamp":1790633929674,"version":"4.1.0"},"reference-count":69,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2020,9,28]],"date-time":"2020-09-28T00:00:00Z","timestamp":1601251200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100004312","name":"Eli Lilly and Company","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004312","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pest Management Science"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Natural products (NPs) have long been a source of insecticidal crop protection products. Like many macrolide NPs, the spinosyns originated from a soil inhibiting microorganism (<jats:italic>Saccharopolyspora spinosa<\/jats:italic>). More than 20\u2009years after initial registration, the spinosyns remain a unique class of NP\u2010based insect control products that presently encompass two insecticidal active ingredients, spinosad, a naturally occurring mixture of spinosyns, and spinetoram, a semi\u2010synthetic spinosyn product. The exploration and exploitation of the spinosyns has, unusually, been tied to an array of computational tools including artificial intelligence (AI)\u2010based quantitative structure activity relationship (QSAR) and most recently computer\u2010aided modeling and design (CAMD). The AI\u2010based QSAR directly lead to the discovery of spinetoram, while the CAMD studies have recently resulted in the discovery and building of a series of synthetic spinosyn mimics. The most recent of these synthetic spinosyn mimics show promise as insecticides targeting lepidopteran insect pests as demonstrated by field studies wherein the efficacy has been shown to be comparable to spinosad and spinetoram. These and a range of other aspects related to the exploration of the spinosyns over the past 30\u2009years are reviewed herein. \u00a9 2020 Society of Chemical Industry<\/jats:p>","DOI":"10.1002\/ps.6073","type":"journal-article","created":{"date-parts":[[2020,9,27]],"date-time":"2020-09-27T08:31:37Z","timestamp":1601195497000},"page":"3637-3649","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":85,"title":["The spinosyns, spinosad, spinetoram, and synthetic spinosyn mimics \u2010 discovery, exploration, and evolution of a natural product chemistry and the impact of computational tools"],"prefix":"10.1002","volume":"77","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0526-7594","authenticated-orcid":false,"given":"Thomas C","family":"Sparks","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary D","family":"Crouse","sequence":"additional","affiliation":[{"name":"Corteva Agriscience Discovery Research  Indianapolis IN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zoltan","family":"Benko","sequence":"additional","affiliation":[{"name":"Corteva Agriscience Discovery Research  Indianapolis IN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Demeter","sequence":"additional","affiliation":[{"name":"Corteva Agriscience Discovery Research  Indianapolis IN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie C","family":"Giampietro","sequence":"additional","affiliation":[{"name":"Corteva Agriscience Discovery Research  Indianapolis IN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Lambert","sequence":"additional","affiliation":[{"name":"Corteva Agriscience Discovery Research  Indianapolis IN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annette V","family":"Brown","sequence":"additional","affiliation":[{"name":"Corteva Agriscience Discovery Research  Indianapolis IN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,9,28]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ps.3744"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ps.4458"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pestbp.2019.09.002"},{"key":"e_1_2_10_5_1","doi-asserted-by":"crossref","unstructured":"Agranova http:\/\/www.agranova.co.uk\/news.aspAccessed 4\u20109\u20102020.","DOI":"10.1177\/2050168420910998"},{"key":"e_1_2_10_6_1","unstructured":"IRAC Insecticide Resistance Action Committee http:\/\/www.irac-online.org. 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