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Chlorpromazine, a phenothiazine compound known as a calmodulin antagonist, appeared the most potent compound. Tacrolimus, a macrolide compound with immunosuppressive activity, was also active. The synergism of chlorpromazine negatively correlated with the sensitivity of the parent strain and mutants of\n                    <jats:italic>B cinerea<\/jats:italic>\n                    . The synergism was highest in a mutant that overexpressed the ATP\u2010binding cassette transporter BcatrD, known to transport DMI fungicides such as oxpoconazole. The synergism of chlorpromazine positively correlated with its potency to enhance the accumulation of oxpoconazole in\n                    <jats:italic>BcatrD<\/jats:italic>\n                    mutants. These results indicate that chlorpromazine is a modulator of BcatrD activity in\n                    <jats:italic>B cinerea<\/jats:italic>\n                    and suggest that mixtures of DMI fungicides with modulators may represent a perspective for the development of new resistance management strategies.\n                  <\/jats:p>\n                  <jats:p>\u00a9 2003 Society of Chemical Industry<\/jats:p>","DOI":"10.1002\/ps.637","type":"journal-article","created":{"date-parts":[[2003,2,14]],"date-time":"2003-02-14T09:06:48Z","timestamp":1045213608000},"page":"294-302","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["Modulators of membrane drug transporters potentiate the activity of the DMI fungicide oxpoconazole against\n                    <i>Botrytis 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