{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T04:47:56Z","timestamp":1792212476683,"version":"4.4.0"},"reference-count":40,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,10,11]],"date-time":"2021-10-11T00:00:00Z","timestamp":1633910400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pest Management Science"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Natural products (NPs) have long been an important source of, and inspiration for, developing novel compounds to control weeds, pathogens and insect pests. In this review, we use a dataset of 800 historic, current and emerging crop protection compounds to explore the influence of NPs on the introduction of new crop protection compounds (fungicides, herbicides, insecticides) as a function of time. NPs, their semisynthetic derivatives (NPDs) and compounds inspired by NPs (NP mimics, NPMs) account for 17% of all crop protection compounds. NPs, NPDs, and NPMs have been a fairly constant source of new agrochemicals over the past 70\u2009years. NP synthetic equivalents (NPSEs) is a fourth group of NP\u2010related crop protection compounds composed of synthetic compounds which by chance also happen to have an NP model (but are not involved in the discovery). If NPSE compounds are also included, then 50% of all crop protection compounds hypothetically could have had a NP origin. Similar trends also hold true for the impact of NPs on the discovery of new modes of action (MoA) or innovation in crop protection compounds as measured by the number of first\u2010in\u2010class compounds. NPs have had the largest impact on the numbers and global sales (2018 USD) of insecticides compared to fungicides and herbicides. The present analysis highlights NPs as a long\u2010standing and continuing source of new chemistry, new MoAs and innovation in crop protection compound discovery. \u00a9 2021 Society of Chemical Industry.<\/jats:p>","DOI":"10.1002\/ps.6653","type":"journal-article","created":{"date-parts":[[2021,9,22]],"date-time":"2021-09-22T02:15:38Z","timestamp":1632276938000},"page":"399-408","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":97,"title":["Impact of natural products on discovery of, and innovation in, crop protection compounds"],"prefix":"10.1002","volume":"78","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0526-7594","authenticated-orcid":false,"given":"Thomas C","family":"Sparks","sequence":"first","affiliation":[{"name":"Agrilucent  Greenfield IN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert J","family":"Bryant","sequence":"additional","affiliation":[{"name":"Agranova  Orpington UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,10,11]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1237227"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ps.4457"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1584\/jpestics.D19-101"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1584\/jpestics.D20-201"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ps.6293"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf60227a012"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pestbp.2013.05.012"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1021\/bk-2015-1204.ch002"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ps.4336"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1021\/bk-2017-1264.ch001"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ps.5350"},{"key":"e_1_2_9_13_1","first-page":"585","volume-title":"Naturally Occurring Insecticides","author":"Jacobson M","year":"1971"},{"key":"e_1_2_9_14_1","first-page":"349","volume-title":"The Future for Insecticides: Needs and Prospects","author":"Casida JE","year":"1974"},{"key":"e_1_2_9_15_1","first-page":"33","volume-title":"Natural Products for Innovative Pest Management","author":"Gubler K","year":"1983"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2009.01.046"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11101-010-9168-y"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1021\/np300024u"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/ps.3744"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/ps.4458"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.1c02616"},{"key":"e_1_2_9_22_1","unstructured":"Fungicide Resistance Action Committee (FRAC).http:\/\/www.frac.info\/Accessed 22 May 2021."},{"key":"e_1_2_9_23_1","unstructured":"Herbicide Resistance Action Committee (HRAC).http:\/\/www.hracglobal.com\/Accessed 24 May 2021."},{"key":"e_1_2_9_24_1","unstructured":"Insecticide Resistance Action Committee.http:\/\/www.irac-online.orgAccessed 20 May 2021."},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pestbp.2020.104587"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/ps.6254"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/ps.6392"},{"key":"e_1_2_9_28_1","unstructured":"WoodA Index of new ISO common names compendium of pesticide common names. 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