{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T22:09:46Z","timestamp":1768082986005,"version":"3.49.0"},"reference-count":65,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,10,29]],"date-time":"2021-10-29T00:00:00Z","timestamp":1635465600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pest Management Science"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Rice blast disease (<jats:italic>Magnaporthe oryzae<\/jats:italic>) is considered the most destructive rice disease all over the world. Dimetindene maleate is used in medication against allergic reactions in humans. Dimetindene maleate used to induce systemic acquired resistance (SAR) in rice (<jats:italic>Oryza sativa<\/jats:italic> L.) in order to protect rice plants from blast disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Dimetindene maleate was not effective against fungus linear growth <jats:italic>in vitro<\/jats:italic>. In glasshouse conditions, dimetindene maleate significantly improved resistance at 25, 50, 125, 250, 500 and 1000\u2009mg\u2009L<jats:sup>\u22121<\/jats:sup> concentrations. Leaf blast severity reached 14.18% on plants treated with the most effective concentration of 125\u2009mg\u2009L<jats:sup>\u22121<\/jats:sup> compared with control plants. In field conditions during both seasons (2016 and 2017), 125\u2009mg\u2009L<jats:sup>\u22121<\/jats:sup> dimetindene maleate decreased the disease severity to 1.1% and 2.7%, respectively, after 30\u2009days of treatment. Also, grain yield was increased to 13.27 and 12.90\u2009t\u2009ha<jats:sup>\u20131<\/jats:sup> in 2016 and 2017 seasons, respectively. Moreover, dimetindene maleate induces some of the indicators for salicylic acid and jasmonic acid pathways via gene expression. These genes include <jats:italic>OsWRKY45<\/jats:italic>, <jats:italic>OsNPR1<\/jats:italic>, <jats:italic>AOS2<\/jats:italic>, <jats:italic>JAMYB<\/jats:italic> and <jats:italic>PBZ1<\/jats:italic> (<jats:italic>OsPR10<\/jats:italic>), recording 15.14\u2010, 16.47\u2010, 5.3\u2010, 5.37\u2010 and 5.1\u2010fold changes, respectively, 12\u2010h postinoculation.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>The results overview investigated the effectiveness of dimetindene maleate for increasing rice resistance to blast disease through inducing SAR in rice plants under glasshouse and field conditions, which could be through the SA defense pathway by expression of genes (<jats:italic>OsWRKY45<\/jats:italic> and <jats:italic>OsNPR1<\/jats:italic>). \u00a9 2021 Society of Chemical Industry.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ps.6673","type":"journal-article","created":{"date-parts":[[2021,10,20]],"date-time":"2021-10-20T14:24:51Z","timestamp":1634739891000},"page":"633-642","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["The potential of dimetindene maleate inducing resistance to blast fungus <i>Magnaporthe oryzae<\/i> through activating the salicylic acid signaling pathway in rice plants"],"prefix":"10.1002","volume":"78","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0083-5310","authenticated-orcid":false,"given":"Elgaly K","family":"Salman","sequence":"first","affiliation":[{"name":"Rice Pathology Research Department Plant Pathology Research Institute, Agricultural Research Center  Kafr El\u2010Sheikh Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kamal E","family":"Ghoniem","sequence":"additional","affiliation":[{"name":"Department of Agricultural Botany, Faculty of Agriculture Kafr El\u2010Sheikh University  Kafr El\u2010Sheikh Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elsayedalaa S","family":"Badr","sequence":"additional","affiliation":[{"name":"Rice Pathology Research Department Plant Pathology Research Institute, Agricultural Research Center  Kafr El\u2010Sheikh Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amero A","family":"Emeran","sequence":"additional","affiliation":[{"name":"Department of Agricultural Botany, Faculty of Agriculture Kafr El\u2010Sheikh University  Kafr El\u2010Sheikh Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,10,29]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2018.07.393"},{"key":"e_1_2_7_3_1","unstructured":"FAOSTAT Food and Agriculture Organization of the United Nations (2020). 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