{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T06:47:36Z","timestamp":1788850056126,"version":"build-2803163510"},"reference-count":41,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,12,8]],"date-time":"2021-12-08T00:00:00Z","timestamp":1638921600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006606","name":"Natural Science Foundation of Tianjin City","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006606","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pest Management Science"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>Plant elicitors are a class of plant protection agents that can stimulate plant immunity against phytopathogen without a potential resistance problem. In searching for novel plant elicitor candidates, a series of novel N\u2010(2\u2010phenyl\u20103\u2010pyridyl) thiadiazole\/isothiazole carboxamide analogs were designed and synthesized.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      <jats:italic>In vitro<\/jats:italic>\n                      bioassay showed that all new compounds exhibited weak direct fungicidal activity. However, compounds\n                      <jats:bold>3b<\/jats:bold>\n                      ,\n                      <jats:bold>3g<\/jats:bold>\n                      ,\n                      <jats:bold>3n<\/jats:bold>\n                      and\n                      <jats:bold>3o<\/jats:bold>\n                      showed broad spectrum of\n                      <jats:italic>in vivo<\/jats:italic>\n                      activity against four plant fungi tested. In particularly,\n                      <jats:bold>3g<\/jats:bold>\n                      showed 80% activity against\n                      <jats:italic>Rhizoctonia solani<\/jats:italic>\n                      in a glasshouse at a concentration of 1\u00a0\u03bcg\u2009mL\n                      <jats:sup>\u20131<\/jats:sup>\n                      . For induction activity of tobacco against tobacco mosaic virus (TMV), compounds\n                      <jats:bold>3c<\/jats:bold>\n                      and\n                      <jats:bold>3v<\/jats:bold>\n                      showed 67% and 68% inhibitory activity, respectively, which were superior to the positive controls ribavirin and ningnanmycin. Compound\n                      <jats:bold>3g<\/jats:bold>\n                      showed moderate induction activity (41%). Reverse transcription quantitative polymerase chain reaction (RT\u2010qPCR) analysis found that,\n                      <jats:bold>3g<\/jats:bold>\n                      could up\u2010regulate expression of genes that are related to reactive oxygen species (ROS), pathogenesis\u2010related protein (PRP) and salicylic acid (SA) signalling.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>\n                      These results indicated that\n                      <jats:bold>3g<\/jats:bold>\n                      as an elicitor candidate might act on the SA signalling pathway. According to our findings, N\u2010(2\u2010phenyl\u20103\u2010pyridyl) thiadiazole\/isothiazole carboxamide analogs might be promising lead scaffolds as a novel plant elicitor for further investigation.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ps.6728","type":"journal-article","created":{"date-parts":[[2021,11,20]],"date-time":"2021-11-20T02:46:11Z","timestamp":1637376371000},"page":"1138-1145","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Synthesis of novel N\u2010(2\u2010phenyl\u20103\u2010pyridyl) thiadiazole\/isothiazole carboxamide analogs as potent plant elicitors"],"prefix":"10.1002","volume":"78","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9752-9186","authenticated-orcid":false,"given":"Dongyan","family":"Yang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Elemento\u2010Organic Chemistry, College of Chemistry Nankai University  Tianjin P. 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