{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T19:46:53Z","timestamp":1792180013321,"version":"4.4.0"},"reference-count":44,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,12,30]],"date-time":"2021-12-30T00:00:00Z","timestamp":1640822400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Basic Research Program of China","doi-asserted-by":"publisher","award":["2017YFD0200504"],"award-info":[{"award-number":["2017YFD0200504"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pest Management Science"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Plant disease is one of the most serious problems in agriculture that can damage crops. Chemical fungicides are widely used to control plant diseases, but have led to resistance and a series of environmental problems. It is, therefore, necessary to develop highly effective and eco\u2010friendly antimicrobial compounds with novel structures.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>A series of novel hydantoin cyclohexyl sulfonamide derivatives were synthesized through an intramolecular condensation reaction. The bioassay results indicated that a majority of the title compounds displayed potent inhibitory activity against <jats:italic>Botrytis cinerea<\/jats:italic>, <jats:italic>Sclerotinia sclerotiorum<\/jats:italic> and <jats:italic>Erwinia carotorora<\/jats:italic>. The <jats:italic>in vivo<\/jats:italic> inhibition rate of compound <jats:bold>3h<\/jats:bold> was 91.01% against <jats:italic>B. cinerea<\/jats:italic>, which was higher than that of iprodione (84.07%). Compound <jats:bold>3w<\/jats:bold> showed excellent antifungal activity against <jats:italic>B. cinerea<\/jats:italic> with a half\u2010maximal effective concentration (EC<jats:sub>50<\/jats:sub>) of 4.80\u2009\u03bcg ml<jats:sup>\u20131<\/jats:sup>, which is lower than that of iprodione. Compound <jats:bold>3q<\/jats:bold> had an EC<jats:sub>50<\/jats:sub> value of 1.44\u2009\u03bcg ml<jats:sup>\u20131<\/jats:sup> against <jats:italic>S. sclerotiorum<\/jats:italic>, which was close to that of iprodione (1.39\u2009\u03bcg ml<jats:sup>\u20131<\/jats:sup>), and the inhibition rate was also similar to that of iprodione. Compounds <jats:bold>3i<\/jats:bold> and <jats:bold>3w<\/jats:bold> had the best inhibition efficacy against <jats:italic>S. sclerotiorum<\/jats:italic>, both on growth of the mycelium and sclerotia and in the greenhouse pot test <jats:italic>in vitro<\/jats:italic>. Further study showed that compounds <jats:bold>3h<\/jats:bold>, <jats:bold>3r<\/jats:bold> and <jats:bold>3s<\/jats:bold> have superb antibacterial activity against <jats:italic>E. carotorora<\/jats:italic> with EC<jats:sub>50<\/jats:sub> values of 2.65, 4.24 and 4.29\u2009\u03bcg ml<jats:sup>\u20131<\/jats:sup> respectively, and were superior to streptomycin sulfate (5.96\u2009\u03bcg ml<jats:sup>\u20131<\/jats:sup>).<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>Because of their excellent antifungal and antibacterial activity against <jats:italic>B. cinerea<\/jats:italic>, <jats:italic>S. sclerotiorum<\/jats:italic> and <jats:italic>E. carotorora<\/jats:italic>, these hydantoin cyclohexyl sulfonamide derivatives could be considered as suitable candidates for new antimicrobial agents. \u00a9 2021 Society of Chemical Industry.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ps.6761","type":"journal-article","created":{"date-parts":[[2021,12,18]],"date-time":"2021-12-18T13:18:50Z","timestamp":1639833530000},"page":"1438-1447","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Synthesis and biological activity of novel hydantoin cyclohexyl sulfonamide derivatives as potential antimicrobial agents in agriculture"],"prefix":"10.1002","volume":"78","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6536-752X","authenticated-orcid":false,"given":"Wei","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Pesticide Science, Plant Protection College Shenyang Agricultural University  Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shen","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pesticide Science, Plant Protection College Shenyang Agricultural University  Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lifeng","family":"Xiao","sequence":"additional","affiliation":[{"name":"Dalian Join King Fine Chemical Co., Ltd.  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