{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T15:34:18Z","timestamp":1776440058322,"version":"3.51.2"},"reference-count":43,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T00:00:00Z","timestamp":1750118400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pest Management Science"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>The application of pesticides remains the most effective method for managing crop pests, weeds and diseases. However, owing to issues such as resistance to pesticides, environmental pollution, health problems and consumer demand for food safety, it is highly desirable to research and develop green and environmentally\u2010friendly novel pesticides.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Twenty\u2010three novel 3\u2010carene\u2010derived diacylthiosemicarbazide compounds were synthesized and characterized. The absolute configuration of the target compounds was also confirmed by single crystal X\u2010ray diffraction. The tautomerization phenomenon of the target compounds was investigated using theoretical calculations. The biological activity assays showed that compounds <jats:bold>DAT21<\/jats:bold>~<jats:bold>DAT23<\/jats:bold> not only exhibited excellent antifungal activity, but also demonstrated outstanding herbicidal activity and significant laccase inhibitory activity. The cytotoxicity results showed that compounds <jats:bold>DAT21<\/jats:bold> and <jats:bold>DAT23<\/jats:bold> displayed lower cytotoxicity towards three normal cells at a concentration of 10\u2009mg\u2009L<jats:sup>\u22121<\/jats:sup>. The action mechanism was further conducted by molecular docking and the chelating property of the target compound with copper ion (Cu<jats:sup>2+<\/jats:sup>).<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>These results revealed that compounds <jats:bold>DAT21<\/jats:bold>~<jats:bold>DAT23<\/jats:bold> may exert excellent pesticidal activity by inhibiting laccase. Therefore, compounds <jats:bold>DAT21<\/jats:bold>~<jats:bold>DAT23<\/jats:bold> could serve as promising novel green pesticidal lead compounds and deserve further research. \u00a9 2025 Society of Chemical Industry.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ps.70004","type":"journal-article","created":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T02:54:44Z","timestamp":1750215284000},"page":"6500-6511","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["High value\u2010added application of renewable natural forest product 3\u2010carene: discovery of diacylthiosemicarbazide compounds as potential laccase inhibitors"],"prefix":"10.1002","volume":"81","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-8008-2599","authenticated-orcid":false,"given":"Yucheng","family":"Cui","sequence":"first","affiliation":[{"name":"School of Chemistry and Chemical Engineering Guangxi University  Nanning People's Republic of 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