{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T02:50:13Z","timestamp":1789267813618,"version":"build-2803163510"},"reference-count":50,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T00:00:00Z","timestamp":1754092800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U24A20409"],"award-info":[{"award-number":["U24A20409"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pest Management Science"],"published-print":{"date-parts":[[2025,12]]},"abstract":"Abstract<\/jats:title>\n \n BACKGROUND<\/jats:title>\n \n Bean aphid (\n Aphis craccivora<\/jats:italic>\n ) is one of the most destructive agricultural pests, causing direct harm by sucking plant sap and indirect damage by transmitting various plant viruses, such as potato virus Y (PVY). Extensive and prolonged use of neonicotinoid insecticides has led to severe resistance in\n A. craccivora<\/jats:italic>\n . Therefore, there is an urgent need to develop new and highly effective insecticides to control aphids.\n <\/jats:p>\n <\/jats:sec>\n \n RESULTS<\/jats:title>\n \n A series of pyrido[1,2\u2010\n a<\/jats:italic>\n ]pyrimidinone compounds containing a dithioacetal moiety were designed and synthesized, and their biological activities were evaluated. Compound\n J1<\/jats:bold>\n demonstrated a median lethal concentration (LC\n 50<\/jats:sub>\n ) of 3.51\u2009\u03bcg\/mL against\n A. craccivora<\/jats:italic>\n , comparable with that of triflumezopyrim (LC\n 50<\/jats:sub>\n \u2009=\u20093.95\u2009\u03bcg\/mL). The 50% effective concentrations (EC\n 50<\/jats:sub>\n ) values for the anti\u2010PVY protective activity of compounds\n J1<\/jats:bold>\n and\n J18<\/jats:bold>\n were 264.55 and 225.45\u2009\u03bcg\/mL, respectively, better than those of ningnanmycin (EC\n 50<\/jats:sub>\n \u2009=\u2009428.11\u2009\u03bcg\/mL) and vanisulfane (EC\n 50<\/jats:sub>\n \u2009=\u2009309.46\u2009\u03bcg\/mL). The results of proteomic analysis, reactive oxygen species generation rate assays, and enzyme activity indicated that compound\n J1<\/jats:bold>\n may act on the central nervous system of\n A. craccivora<\/jats:italic>\n , inducing mitochondrial damage in neurons and ultimately leading to pest mortality. In addition, compound\n J1<\/jats:bold>\n markedly enhanced the activity of defense enzymes and regulated the plant hormone signaling pathways in\n Nicotiana tabacum<\/jats:italic>\n cv. k326, thereby strengthening the plant's defense response and disease resistance against PVY.\n <\/jats:p>\n <\/jats:sec>\n \n CONCLUSION<\/jats:title>\n \n Compound\n J1<\/jats:bold>\n demonstrated potent aphicidal efficacy and remarkable anti\u2010PVY protective properties, offering novel insights for the integrated management of\n A. craccivora<\/jats:italic>\n and the PVY they transmit. \u00a9 2025 Society of Chemical Industry.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/ps.70090","type":"journal-article","created":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T07:49:00Z","timestamp":1754120940000},"page":"7764-7776","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Pyrido[1,2\u2010\n \n a<\/i>\n <\/scp>\n ]pyrimidinone mesoionic compounds containing dithioacetal moiety: design, synthesis, insecticidal\/antiviral activity and mechanism"],"prefix":"10.1002","volume":"81","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-9124-7716","authenticated-orcid":false,"given":"Duanpu","family":"Wu","sequence":"first","affiliation":[{"name":"State Key Laboratory of Green Pesticide, Center for R&D of Fine Chemicals Guizhou University Guiyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shimei","family":"Mu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Green Pesticide, Center for R&D of Fine Chemicals Guizhou University Guiyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Xu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Green Pesticide, Center for R&D of Fine Chemicals Guizhou University Guiyang 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