{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T10:50:50Z","timestamp":1787827850142,"version":"build-2784847793"},"reference-count":43,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T00:00:00Z","timestamp":1755216000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32160109;31800294"],"award-info":[{"award-number":["32160109;31800294"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2021B1515420002"],"award-info":[{"award-number":["2021B1515420002"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019006","name":"State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Ministry of Education","doi-asserted-by":"publisher","award":["2020\u2010A09"],"award-info":[{"award-number":["2020\u2010A09"]}],"id":[{"id":"10.13039\/501100019006","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pest Management Science"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>\n                      <jats:italic>Diaphorina citri<\/jats:italic>\n                      is one of the most severe pests affecting citrus production worldwide. Our previous research identified a series of quassinoids that exhibit insecticidal activity against\n                      <jats:italic>D. citri<\/jats:italic>\n                      adults\n                      <jats:italic>.<\/jats:italic>\n                      However, the larvae of\n                      <jats:italic>D. citri<\/jats:italic>\n                      also pose a significant threat to the citrus industry. In an effort to discover novel larvicidal lead compounds, a systematic phytochemical study on the relatively understudied fruits of\n                      <jats:italic>Picrasma quassioides<\/jats:italic>\n                      was conducted, and the insecticidal mechanism was also explored preliminarily.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Ten new (\n                      <jats:bold>1<\/jats:bold>\n                      \u2013\n                      <jats:bold>10<\/jats:bold>\n                      ) and 15 known quassinoids (\n                      <jats:bold>11<\/jats:bold>\n                      \u2013\n                      <jats:bold>25<\/jats:bold>\n                      ) were isolated from\n                      <jats:italic>P. quassioides<\/jats:italic>\n                      fruits. All these new compounds possess a hydroxyl group at C\u201014 except for compound\n                      <jats:bold>5<\/jats:bold>\n                      , which is a rare example of quassinoid with a double bond located at C\u201014 and C\u201015. In terms of biological actions, compounds\n                      <jats:bold>2<\/jats:bold>\n                      ,\n                      <jats:bold>3<\/jats:bold>\n                      ,\n                      <jats:bold>5<\/jats:bold>\n                      ,\n                      <jats:bold>7<\/jats:bold>\n                      ,\n                      <jats:bold>10<\/jats:bold>\n                      \u2013\n                      <jats:bold>16<\/jats:bold>\n                      and\n                      <jats:bold>18<\/jats:bold>\n                      \u2013\n                      <jats:bold>23<\/jats:bold>\n                      had potent insecticidal activity. Preliminary structure and activity relationship (SAR)\u00a0studies have shown that the insecticidal activity of quassinoids is closely related to the types of substituents at positions C\u201012, C\u201014 and C\u201016. Real\u2010time quantitative polymerase chain reaction analysis demonstrated that compounds\n                      <jats:bold>7<\/jats:bold>\n                      ,\n                      <jats:bold>11<\/jats:bold>\n                      and\n                      <jats:bold>12<\/jats:bold>\n                      disturbed the expression of cytochrome P450, carboxylate esterase and glutathione\n                      <jats:italic>S<\/jats:italic>\n                      \u2010transferase genes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>\n                      Quassinoids isolated from fruits of\n                      <jats:italic>P. quassioides<\/jats:italic>\n                      demonstrate significant efficacy in managing the larvae of\n                      <jats:italic>D. citri<\/jats:italic>\n                      . These active compounds may serve as crucial lead structures for the development of highly effective plant\u2010derived insecticides and control citrus Huanglongbing which mainly transmitted by\n                      <jats:italic>D. citri<\/jats:italic>\n                      . \u00a9 2025 Society of Chemical Industry.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ps.70131","type":"journal-article","created":{"date-parts":[[2025,8,16]],"date-time":"2025-08-16T03:01:31Z","timestamp":1755313291000},"page":"8226-8238","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["C\u201014 oxygenated quassinoids with control effect against larvae of\n                    <scp>\n                      <i>Diaphorina citri<\/i>\n                    <\/scp>\n                    Kuwayama from fruits of\n                    <scp>\n                      <i>Picrasma quassioides<\/i>\n                    <\/scp>"],"prefix":"10.1002","volume":"81","author":[{"given":"Li\u2010Ming","family":"Zhan","sequence":"first","affiliation":[{"name":"Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Ministry of Education of China), Guangxi Key Laboratory of Chemistry and Molecular Engineering of Medicinal Resources\uff0cUniversity Engineering Research Center for Chemistry of Characteristic Medicinal Resources (Guangxi) School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University  Guilin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting\u2010Mi","family":"Yang","sequence":"additional","affiliation":[{"name":"Guangxi Laboratory of Germplasm Innovation and Utilization of Specialty Commercial Crops in North Guangxi\/Guangxi Academy of Specialty Crops  Guilin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Han","sequence":"additional","affiliation":[{"name":"Guangxi Laboratory of Germplasm 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