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Chalcone is a simple scaffold for a number of natural compounds and is extensively found in plants. Due to the presence of active \u03b1, \u03b2\u2010unsaturated carbonyl groups, chalcone and its derivatives display a wide array of biological activities. Chemically, chalcone can be modified and synthesized easily to produce a variety of compounds with different structures. It is these properties that render chalcone analogs an effective tool for modifying the biological activity of pesticide molecules. This paper synthesizes the relevant research reports and patents of chalcone compounds with pesticide activity in the past 20\u2009years. By summarizing the past research as well as combining the current development trend, we focus on five future directions of chalcone development, aiming to provide an effective reference value for the research of chalcone structure in pesticides. \u00a9 2025 Society of Chemical Industry.<\/jats:p>","DOI":"10.1002\/ps.70179","type":"journal-article","created":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T12:25:51Z","timestamp":1756729551000},"page":"14-41","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Recent advances in the pesticide activities of chalcone derivatives"],"prefix":"10.1002","volume":"82","author":[{"given":"Pengxiang","family":"Guo","sequence":"first","affiliation":[{"name":"Engineering Research Center of Agricultural Microbiology Technology, Ministry of Education Heilongjiang University  Harbin China"},{"name":"Engineering Research Center of Pesticide of Heilongjiang Province Heilongjiang University  Harbin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7832-7212","authenticated-orcid":false,"given":"Hongliang","family":"Xu","sequence":"additional","affiliation":[{"name":"Engineering Research Center of Agricultural Microbiology Technology, Ministry of Education Heilongjiang University  Harbin China"},{"name":"Engineering Research Center of Pesticide of Heilongjiang Province Heilongjiang University  Harbin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wanjie","family":"Zhang","sequence":"additional","affiliation":[{"name":"Engineering Research Center of Agricultural Microbiology Technology, Ministry of Education Heilongjiang University  Harbin China"},{"name":"Engineering Research Center of Pesticide of Heilongjiang Province Heilongjiang University  Harbin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuhao","family":"Shi","sequence":"additional","affiliation":[{"name":"Engineering Research Center of Agricultural Microbiology Technology, Ministry of Education Heilongjiang University  Harbin China"},{"name":"Engineering Research Center of Pesticide of Heilongjiang Province Heilongjiang University  Harbin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wensheng","family":"Xiang","sequence":"additional","affiliation":[{"name":"School of Life Sciences Northeast Agricultural University  Harbin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fengshan","family":"Yang","sequence":"additional","affiliation":[{"name":"Engineering Research Center of Agricultural Microbiology Technology, Ministry of Education &amp; 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