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Therefore, there is an urgent need to develop effective and eco\u2010friendly plant\u2010based antifungal compounds.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      A series of rosin\u2010based Schiff base derivatives were synthesized, and all compounds were charactered using FT\u2010IR,\n                      <jats:sup>1<\/jats:sup>\n                      H NMR,\n                      <jats:sup>13<\/jats:sup>\n                      C NMR and LC\u2013MS.\n                      <jats:italic>In vitro<\/jats:italic>\n                      antifungal activity evaluation revealed that compound 4o (4o) exhibited excellent antifungal activity against\n                      <jats:italic>Fusarium graminearum<\/jats:italic>\n                      , with an EC\n                      <jats:sub>50<\/jats:sub>\n                      value of 1.088\u2009\u03bcg\/mL. The preliminary structure\u2013activity relationship analysis suggested that introducing electron\u2010donating groups onto the benzene ring enhanced antifungal activity. Additionally, mycelial morphological observation indicated that after treatment with 4o, the mycelium exhibited noticeable shrinkage on the outside, and a significant accumulation of reactive oxygen species inside. Finally, mycelial physiological index measurement showed that after treatment with 4o, mycelial cell membrane permeability increased to 65.56%, malondialdehyde content rose by 60.17%, and catalase enzyme activity significantly decreased by 94.67%. The results of molecular dynamics calculations indicate that there is a strong interaction between 4o and CAT proteins, with van der Waals forces playing a major role.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>This study provides theoretical support for the development of a novel plant\u2010based antifungal compound for agricultural protection. \u00a9 2025 Society of Chemical Industry.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ps.70183","type":"journal-article","created":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T10:03:29Z","timestamp":1756893809000},"page":"217-227","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Synthesis and antifungal activity evaluation of novel dehydroabietic acid\u2010based\n                    <scp>Schiff<\/scp>\n                 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