{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T12:37:28Z","timestamp":1789907848354,"version":"4.0.1"},"reference-count":44,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T00:00:00Z","timestamp":1764115200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T00:00:00Z","timestamp":1764115200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pest Management Science"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>Aphids have primarily been controlled by traditional chemical insecticides over the past decades, leading to health risks for honey bees. By contrast, plant volatiles such as methyl salicylate (MeSA) can not only repel aphids, but also attract their natural enemies, while being safe for bees, thus showing a promising prospect in aphid management. Our research group has previously discovered more active compounds for aphid management based on MeSA. Therefore, further structural optimization with MeSA as the lead compound is worth investigating.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Through the structural combination of nerol or citronellol with MeSA, two classes of derivatives were synthesized. The citronellol derivatives (\n                      <jats:bold>6a<\/jats:bold>\n                      \u2013\n                      <jats:bold>6q<\/jats:bold>\n                      ) exhibited superior binding affinities with\n                      <jats:italic>Acyrthosiphon pisum<\/jats:italic>\n                      OBP9 and better repelling activity against\n                      <jats:italic>A.\u2009pisum<\/jats:italic>\n                      than the nerol derivatives (\n                      <jats:bold>4a<\/jats:bold>\n                      \u2013\n                      <jats:bold>4q<\/jats:bold>\n                      ), among which\n                      <jats:bold>6d<\/jats:bold>\n                      showed the strongest repellent activity, with a repellent proportion of 60.9%. Bearing binding constant ranged from 0.31 to 3.79\u2009\u03bc\n                      <jats:sc>M<\/jats:sc>\n                      , both citronellol and nerol derivatives had good binding affinity to\n                      <jats:italic>Harmonia axyridis<\/jats:italic>\n                      OBP15. Moreover, the derivatives\n                      <jats:bold>6d<\/jats:bold>\n                      and\n                      <jats:bold>6h<\/jats:bold>\n                      showed better attractive activities to male\n                      <jats:italic>H.\u2009axyridis<\/jats:italic>\n                      (choice rate: 63.9% and 67.2%) than the lead MeSA (63.3%). Mechanism study revealed that the citronellol derivatives owning the saturated conformation to offer increased flexibility exhibited superior bioactivity compared to the nerol derivatives with the\n                      <jats:italic>cis<\/jats:italic>\n                      conformation. Besides,\n                      <jats:bold>6d<\/jats:bold>\n                      has low toxicity to honeybees (\n                      <jats:italic>Apis mellifera<\/jats:italic>\n                      ).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>\n                      The citronellol derivative\n                      <jats:bold>6d<\/jats:bold>\n                      exhibited both aphid\u2010repelling activity and ladybug\u2010attracting activity, while being friendly to bees.\n                      <jats:bold>6d<\/jats:bold>\n                      can be considered as a novel aphid control agent for aphid control in sustainable agriculture. \u00a9 2025 Society of Chemical Industry.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ps.70407","type":"journal-article","created":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T10:02:27Z","timestamp":1764151347000},"page":"2708-2718","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Novel methyl salicylate derivatives containing nerol and citronellol moieties for improved\n                    <i>Acyrthosiphon pisum<\/i>\n                    management"],"prefix":"10.1002","volume":"82","author":[{"given":"Shi\u2010Xiang","family":"Pan","sequence":"first","affiliation":[{"name":"Innovation Center of Pesticide Research, Department of Applied Chemistry, College of Science China Agricultural University  Beijing PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5615-2730","authenticated-orcid":false,"given":"Zhao\u2010Kai","family":"Yang","sequence":"additional","affiliation":[{"name":"Innovation Center of Pesticide Research, Department of Applied Chemistry, College of Science China Agricultural University  Beijing PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Qu","sequence":"additional","affiliation":[{"name":"Institute of Plant Protection Beijing Academy of Agriculture and Forestry Sciences  Beijing PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Liu","sequence":"additional","affiliation":[{"name":"Innovation Center of Pesticide Research, Department of Applied Chemistry, College of Science China Agricultural University  Beijing PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuo","family":"Shi","sequence":"additional","affiliation":[{"name":"Innovation Center of Pesticide Research, Department of Applied Chemistry, College of Science China Agricultural University  Beijing PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao\u2010Guo","family":"Qin","sequence":"additional","affiliation":[{"name":"Department of Entomology and MOA Key Laboratory of Pest Monitoring and Green Management, College of Plant Protection China Agricultural University  Beijing PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Luo","sequence":"additional","affiliation":[{"name":"College of Plant Protection Yangzhou University  Yangzhou PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0118-402X","authenticated-orcid":false,"given":"Xin\u2010Ling","family":"Yang","sequence":"additional","affiliation":[{"name":"Innovation Center of Pesticide Research, Department of Applied Chemistry, College of Science China Agricultural University  Beijing PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,26]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.crvi.2010.03.009"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/afe.12073"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaa1190"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ps.5606"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep14621"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/nph.12145"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbi.2025.102708"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tifs.2022.05.007"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.plantsci.2020.110457"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1104\/pp.104.049981"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/nph.14475"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/ps.70313"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02098393"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/ps.5787"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1080\/09670874.2022.2088879"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1005555300476"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10886-007-9370-6"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/ee\/nvx201"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/ps.6956"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11356-017-9483-6"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.copbio.2013.12.006"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1570-7458.2007.00569.x"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/nph.14274"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02036192"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/jisesa\/ieaa078"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10886-005-5923-8"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/ps.7245"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11829-013-9281-0"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1744-7348.2008.00300.x"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0023608"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2021.12.054"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/imb.12295"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0032759"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ibmb.2021.103528"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2022.829766"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocontrol.2018.11.008"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm050040j"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/prot.21123"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/pro.5560020916"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.2c04126"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.4c04053"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.5c04008"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocontrol.2011.11.006"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.0c03854"}],"container-title":["Pest Management Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/scijournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ps.70407","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/scijournals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ps.70407","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/scijournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ps.70407","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,15]],"date-time":"2026-02-15T03:26:06Z","timestamp":1771125966000},"score":1,"resource":{"primary":{"URL":"https:\/\/scijournals.onlinelibrary.wiley.com\/doi\/10.1002\/ps.70407"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,26]]},"references-count":44,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["10.1002\/ps.70407"],"URL":"https:\/\/doi.org\/10.1002\/ps.70407","archive":["Portico"],"relation":{},"ISSN":["1526-498X","1526-4998"],"issn-type":[{"value":"1526-498X","type":"print"},{"value":"1526-4998","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,26]]},"assertion":[{"value":"2024-12-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}