{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T19:57:58Z","timestamp":1789588678788,"version":"build-2803163510"},"reference-count":41,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T00:00:00Z","timestamp":1765670400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T00:00:00Z","timestamp":1765670400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pest Management Science"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>Natural products are an important source for the development of herbicides. Tenuazonic acid (TeA) is a natural phytotoxin produced by phytopathogenic fungi that strongly inhibits photosystem II (PS II) by preventing electron flow from the primary quinone acceptor (QA) of PS II to the secondary quinone acceptor (QB), thereby directly disrupting the key chain of plant photosynthesis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      A series of TeA derivatives were rationally designed and synthesized based on the PS II D1 protein, and their herbicidal activities were evaluated. Compound\n                      <jats:bold>C11<\/jats:bold>\n                      achieved &gt;\u200990% control of\n                      <jats:italic>Abutilon theophrasti<\/jats:italic>\n                      and\n                      <jats:italic>Portulaca oleracea<\/jats:italic>\n                      at 37.5\u2009g\u2009a.i.\u2009ha\n                      <jats:sup>\u22121<\/jats:sup>\n                      , whereas atrazine achieved &lt;\u200950% at the same rate. Meanwhile, compound\n                      <jats:bold>C11<\/jats:bold>\n                      exhibited outstanding crop safety in cotton, peanut, wheat, corn, and rice at 300\u2009g a.i.\u2009ha\n                      <jats:sup>\u22121<\/jats:sup>\n                      and performed better than atrazine. Furthermore, it was found to be less toxic to zebrafish embryos than atrazine and TeA. Molecular simulation analysis and chlorophyll fluorescence evaluation revealed that compound\n                      <jats:bold>C11<\/jats:bold>\n                      exhibits a stronger binding affinity to the PS II D1 protein.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>\n                      Compound\n                      <jats:bold>C11<\/jats:bold>\n                      , with excellent herbicidal activity and remarkable safety in crops and zebrafish embryos, was discovered, and it can be regarded as a potential lead compound for the development of a new type of PS II\u2010inhibiting herbicide. \u00a9 2025 Society of Chemical Industry.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ps.70456","type":"journal-article","created":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T06:35:53Z","timestamp":1765780553000},"page":"3331-3342","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Rational design and herbicidal activity of tenuazonic acid derivatives based on photosystem\n                    <scp>II D1<\/scp>\n                    protein"],"prefix":"10.1002","volume":"82","author":[{"given":"Jiahui","family":"Zhang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Green Pesticide Center for R&amp;D of Fine Chemicals of Guizhou University  Guiyang P. 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