{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T01:03:35Z","timestamp":1784682215648,"version":"3.55.0"},"reference-count":42,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,1,25]],"date-time":"2026-01-25T00:00:00Z","timestamp":1769299200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,25]],"date-time":"2026-01-25T00:00:00Z","timestamp":1769299200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017691","name":"Guangxi Key Research and Development Program","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100017691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pest Management Science"],"published-print":{"date-parts":[[2026,4]]},"abstract":"Abstract<\/jats:title>\n \n BACKGROUND<\/jats:title>\n Selenium\u2010containing organic compounds have gained attention for their diverse biological activities. Aromatic selenocyanates, in particular, show promise in medicinal chemistry, but their potential in agriculture\u2009\u2013\u2009especially against plant pathogenic bacteria\u2009\u2013\u2009remains unexplored. With the rise of bacterial resistance and limited effective bactericides, new agrochemicals with strong, broad\u2010spectrum activity are urgently needed.<\/jats:p>\n <\/jats:sec>\n \n RESULTS<\/jats:title>\n \n Twenty\u2010three aromatic selenocyanates were synthesized and tested against three major phytopathogenic bacteria:\n Xanthomonas citri<\/jats:italic>\n subsp.\n citri<\/jats:italic>\n (citrus canker),\n X. oryzae<\/jats:italic>\n pv.\n oryzae<\/jats:italic>\n (rice blight), and\n X. oryzae<\/jats:italic>\n pv.\n oryzicola<\/jats:italic>\n (rice leaf streak). Compounds\n 3<\/jats:bold>\n ,\n 7<\/jats:bold>\n ,\n 8<\/jats:bold>\n ,\n 12<\/jats:bold>\n ,\n 15<\/jats:bold>\n , and\n 16<\/jats:bold>\n exhibited exceptional antibacterial activity, with half\u2010maximal effective concentration (EC\n 50<\/jats:sub>\n ) values generally below 1\u2009\u03bcg\u2009mL\n \u22121<\/jats:sup>\n ; significantly lower than commercial controls (thiodiazole\u2010copper and tebuconazole, EC\n 50<\/jats:sub>\n \u2009>\u200963\u2009\u03bcg\u2009mL\n \u22121<\/jats:sup>\n ). Structure\u2013activity relationship (SAR) analysis showed that\n para<\/jats:italic>\n \u2010fluoro,\n ortho<\/jats:italic>\n \u2010cyano, and 3,4\u2010dichloro substitutions enhanced activity; pyridine\u2010based analogs outperformed others; and\n \u03b1<\/jats:italic>\n \u2010selenocyanato acetophenones were less active than benzyl\u2010type derivatives. Converting \u2010SeCN to diselenide or thiocyanate (\u2010SCN) greatly reduced potency. Molecular docking revealed that the \u2010SeCN group binds strongly to the ParE subunit of topoisomerase IV, confirmed its role as a key pharmacophore.\n In vivo<\/jats:italic>\n tests showed compound\n 12<\/jats:bold>\n achieved 85.19% disease control efficiency at 200\u2009ppm, effectively suppressing bacterial growth in citrus plants.\n <\/jats:p>\n <\/jats:sec>\n \n CONCLUSION<\/jats:title>\n \n This study is the first to systematically demonstrate the potential antibacterial activity of aromatic selenocyanates against phytopathogens, both\n in vitro<\/jats:italic>\n and\n in vivo<\/jats:italic>\n , highlighting the \u2010SeCN group as a critical motif for agrochemical design. These findings open new avenues for developing selenium\u2010based antibacterial agents in agriculture. \u00a9 2026 Society of Chemical Industry.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/ps.70514","type":"journal-article","created":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T06:40:42Z","timestamp":1769409642000},"page":"3942-3954","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Excellent inhibitory activity of aromatic selenocyanates against phytopathogenic bacterium and structure\u2013activity relationship"],"prefix":"10.1002","volume":"82","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-6864-2685","authenticated-orcid":false,"given":"Zhiping","family":"Liu","sequence":"first","affiliation":[{"name":"Guangxi Key Laboratory of Natural Polymer Chemistry and Physics, Nanning Normal University Nanning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunrui","family":"Cai","sequence":"additional","affiliation":[{"name":"Guangxi Key Laboratory of Natural Polymer Chemistry and Physics, Nanning Normal University Nanning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenhao","family":"Tian","sequence":"additional","affiliation":[{"name":"Guangxi Key Laboratory of Natural Polymer Chemistry and Physics, Nanning Normal University Nanning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Hu","sequence":"additional","affiliation":[{"name":"Guangxi Key Laboratory of Natural Polymer Chemistry and Physics, Nanning Normal University Nanning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taichen","family":"Yang","sequence":"additional","affiliation":[{"name":"Guangxi Key Laboratory of Natural Polymer Chemistry and Physics, Nanning Normal University Nanning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7366-5239","authenticated-orcid":false,"given":"Yanmin","family":"Huang","sequence":"additional","affiliation":[{"name":"Guangxi Key Laboratory of Natural Polymer Chemistry and Physics, Nanning Normal University Nanning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiguo","family":"Li","sequence":"additional","affiliation":[{"name":"Guangxi Tianyuan Biochemical Co. 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