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This escalating resistance underscores an urgent need to develop novel insecticides with unique structures and distinct modes\u2010of\u2010action.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      In this study, a series of oxime ether sulfonamide derivatives containing cyclopropane fragments were designed and synthesized using the alkyl oxime ether ethanesulfonamide compound ZY\u20109 as the lead compound. Indoor insecticidal bioassay showed that compound 3a\u201028 displays the greatest insecticidal activity against\n                      <jats:italic>P.\u2009xylostella<\/jats:italic>\n                      with a median lethal concentration (LC\n                      <jats:sub>50<\/jats:sub>\n                      ) value of 13.30\u2009mg\u2009L\n                      <jats:sup>\u20131<\/jats:sup>\n                      , which was comparable to those of the commercial insecticides diflubenzuron (13.90\u2009mg\u2009L\n                      <jats:sup>\u20131<\/jats:sup>\n                      ) and diafenthiuron (14.74\u2009mg\u2009L\n                      <jats:sup>\u20131<\/jats:sup>\n                      ). Synergism studies indicated that compound 3a\u201028 presents a synergistic effect in combination with diafenthiuron, indoxacarb, chlorfenapyr and abamectin. Field trials demonstrated that compound 3a\u201028 achieved 62.58% control efficacy, which was comparable to that of diafenthiuron. Morphological observation of the larvae revealed severe damage to the body surface, particularly to the setal sockets and epidermal collapse. Biochemical analysis results showed that compound 3a\u201028 could increase the chitin content and inhibit the chitinase activity [Median inhibitory concentration (IC\n                      <jats:sub>50<\/jats:sub>\n                      )\u2009=\u200914.10\u2009mg\u2009L\n                      <jats:sup>\u20131<\/jats:sup>\n                      ]. Molecular docking confirmed that compound 3a\u201028 stably binds to the active pocket of chitinase (\n                      <jats:italic>Of<\/jats:italic>\n                      ChtI). Additionally, preliminary toxicity evaluation results demonstrated that compound 3a\u201028 exhibits excellent biosafety.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>\n                      The novel cyclopropane\u2010containing oxime ether sulfonamide derivative 3a\u201028 is a highly promising insecticide candidate against\n                      <jats:italic>P.\u2009xylostella<\/jats:italic>\n                      , featuring a unique chitinase\u2010inhibiting mechanism. The findings of this study lay a solid foundation for the future development of insecticides. \u00a9 2026 Society of Chemical Industry.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ps.70578","type":"journal-article","created":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T06:45:44Z","timestamp":1768891544000},"page":"4618-4631","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Design, synthesis and insecticidal activity evaluation of novel oxime ether sulfonamide derivatives containing cyclopropane fragments against\n                    <scp>\n                      <i>Plutella xylostella<\/i>\n                    <\/scp>"],"prefix":"10.1002","volume":"82","author":[{"given":"Yongmin","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Pesticide Science College of Plant Protection, Shenyang Agricultural University  Shenyang 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