{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T05:43:33Z","timestamp":1776059013462,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T00:00:00Z","timestamp":1769558400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T00:00:00Z","timestamp":1769558400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pest Management Science"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>Streptochlorin, a marine indole alkaloid with broad\u2010spectrum bioactivity, has been structurally modified by introducing sulfonamide at the 3\u2010position of the indole scaffold to enhance its antifungal potential.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      A series of sulfonamide\u2010containing derivatives were designed, synthesized, and evaluated against seven phytopathogenic fungi. Notably, derivatives\n                      <jats:bold>D35<\/jats:bold>\n                      \u2013\n                      <jats:bold>D37<\/jats:bold>\n                      exhibited potent antifungal activity, demonstrating &gt;60% inhibition against most tested fungi and\u2009&gt;\u200985% efficacy against\n                      <jats:italic>Valsa mali<\/jats:italic>\n                      . Structure\u2013activity relationship (SAR) analysis revealed that 3\u2010phenylsulfonamide substitution conferred optimal activity. Molecular docking studies suggested that these derivatives likely targeted the cytochrome\n                      <jats:italic>bc<\/jats:italic>\n                      <jats:sub>1<\/jats:sub>\n                      complex, implicating fungal respiration disruption as a potential mode of action.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>\n                      The 3\u2010phenylsulfonamide\u2010modified streptochlorin derivatives exhibited potent antifungal activity, with\n                      <jats:bold>D35<\/jats:bold>\n                      \u2010\n                      <jats:bold>D37<\/jats:bold>\n                      showing particular efficacy. Their successful synthesis offers a novel antifungal scaffold, while preliminary studies suggest potential cytochrome\n                      <jats:italic>bc<\/jats:italic>\n                      <jats:sub>1<\/jats:sub>\n                      complex inhibition as a mode of action. \u00a9 2026 Society of Chemical Industry.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ps.70583","type":"journal-article","created":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T05:26:23Z","timestamp":1769664383000},"page":"4679-4687","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Streptochlorin\u2010derived sulfonamides: discovery of novel antifungal scaffold through structural modification and\n                    <scp>SAR<\/scp>\n                    analysis"],"prefix":"10.1002","volume":"82","author":[{"given":"Yan","family":"Wang","sequence":"first","affiliation":[{"name":"Jiangsu Key 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