{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T18:29:57Z","timestamp":1791916197415,"version":"4.3.4"},"reference-count":35,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T00:00:00Z","timestamp":1769558400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T00:00:00Z","timestamp":1769558400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pest Management Science"],"published-print":{"date-parts":[[2026,5]]},"abstract":"Abstract<\/jats:title>\n \n BACKGROUND<\/jats:title>\n Plant\u2010derived natural product insecticides exhibit notable advantages over traditional chemical insecticides, including high target selectivity, enhanced biodegradability with no residual accumulation, and minimal environmental impact. These properties align with the developmental imperatives of green agriculture, establishing this field as a priority area in insecticide research and development.<\/jats:p>\n <\/jats:sec>\n \n RESULTS<\/jats:title>\n \n Phenolic compounds are a crucial source of plant\u2010derived insecticides. Twenty\u2010four compounds, including two new bibenzyls, dendronosides A\u2009\u2212\u2009B (\n 1<\/jats:bold>\n \u2013\n 2<\/jats:bold>\n ) and three novel flavone C\u2010glycosides, dendronosides C\u2009\u2212\u2009E (\n 3<\/jats:bold>\n \u2013\n 5<\/jats:bold>\n ) were isolated from\n Dendrobium nobile<\/jats:italic>\n . Their structures were elucidated by spectroscopic data analysis, ECD calculations, and HPLC characterization of acid\u2010hydrolyzed and derivatized monosaccharides. The insecticidal activity of these compounds was evaluated against\n Acyrthosiphon pisum<\/jats:italic>\n and\n Sitobion avenae.<\/jats:italic>\n Compound\n 5<\/jats:bold>\n not only demonstrated notable oral toxicity against\n A. pisum<\/jats:italic>\n , with an LC\n 50<\/jats:sub>\n value of 181.6\u2009\u03bcg\u2009mL\n \u22121<\/jats:sup>\n , but also exhibited remarkable repellency against\n A. pisum<\/jats:italic>\n , achieving a repellency index of 1.0 at 400\u2009\u03bcg\u2009mL\n \u22121<\/jats:sup>\n . In\n A. pisum<\/jats:italic>\n exposed to compound\n 5<\/jats:bold>\n , epidermal shrinkage and mouthpart retraction are the dominant toxic symptoms observed. The insecticidal activity of compound\n 5<\/jats:bold>\n is presumably attributable to its interference with the activities of chitinase and GST. Molecular docking analyses revealed that compound\n 5<\/jats:bold>\n binds tightly to\n OfChtI<\/jats:italic>\n via multiple stable hydrogen bonds, indicative of a strong binding affinity between this compound and the target enzyme.\n <\/jats:p>\n <\/jats:sec>\n \n CONCLUSION<\/jats:title>\n \n These findings demonstrate that flavone glycosides isolated from\n D. nobile<\/jats:italic>\n , especially dendronoside E (\n 5<\/jats:bold>\n ), hold great potential as candidates in developing plant\u2010derived insecticidal lead compounds. \u00a9 2026 Society of Chemical Industry.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/ps.70592","type":"journal-article","created":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T09:46:45Z","timestamp":1769593605000},"page":"4780-4791","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Bibenzyls and flavone glycosides from\n \n Dendrobium nobile<\/i>\n <\/scp>\n as potential plant\u2010derived insecticides against\n \n Acyrthosiphon pisum<\/i>\n <\/scp>\n and\n \n Sitobion avenae<\/i>\n <\/scp>"],"prefix":"10.1002","volume":"82","author":[{"given":"Meng","family":"Yang","sequence":"first","affiliation":[{"name":"School of Pharmacy Henan University of Chinese Medicine Zhengzhou China"},{"name":"The Engineering and Technology Research Center for Chinese Medicine Development of Henan Province Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi\u2010You","family":"Hao","sequence":"additional","affiliation":[{"name":"School of Pharmacy Henan University of Chinese Medicine Zhengzhou China"},{"name":"The Engineering and Technology Research Center for Chinese Medicine Development of Henan Province Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao\u2010Lan","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Pharmacy Henan University of Chinese Medicine Zhengzhou China"},{"name":"The Engineering and Technology Research Center for Chinese Medicine Development of Henan Province Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi\u2010Xia","family":"Liu","sequence":"additional","affiliation":[{"name":"Chishui Zhil\u00fc Dendrobium Hairpin Ecological Park Development Co., Ltd. Zunyi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao\u2010Yuan","family":"Xiao","sequence":"additional","affiliation":[{"name":"School of Pharmacy Henan University of Chinese Medicine Zhengzhou China"},{"name":"The Engineering and Technology Research Center for Chinese Medicine Development of Henan Province Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun\u2010Yang","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Pharmacy Henan University of Chinese Medicine Zhengzhou China"},{"name":"The Engineering and Technology Research Center for Chinese Medicine Development of Henan Province Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu\u2010Dong","family":"Ma","sequence":"additional","affiliation":[{"name":"School of Pharmacy Henan University of Chinese Medicine Zhengzhou China"},{"name":"The Engineering and Technology Research Center for Chinese Medicine Development 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