{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T22:01:16Z","timestamp":1792706476046,"version":"4.5.0"},"reference-count":42,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T00:00:00Z","timestamp":1769558400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T00:00:00Z","timestamp":1769558400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100018542","name":"Natural Science Foundation of Sichuan Province","doi-asserted-by":"publisher","award":["2024NSFSC1316)"],"award-info":[{"award-number":["2024NSFSC1316)"]}],"id":[{"id":"10.13039\/501100018542","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pest Management Science"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>The misuse, abuse and long\u2010term application of fungicides have led to a continuous increase in the resistance of plant pathogenic fungi. Therefore, the development of fungicides with novel structure, broad\u2010spectrum inhibition and high efficiency has become an urgent challenge.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      This study designed and synthesized 40 novel oxime ester amide derivatives and investigated their antifungal activity, most of the target compounds had the best inhibitory effect on\n                      <jats:italic>Sclerotinia sclerotiorum<\/jats:italic>\n                      . Among the target compounds, compounds\n                      <jats:bold>7c<\/jats:bold>\n                      and\n                      <jats:bold>7d<\/jats:bold>\n                      exhibited the best\n                      <jats:italic>in vitro<\/jats:italic>\n                      inhibitory activity against\n                      <jats:italic>S. sclerotiorum<\/jats:italic>\n                      , the median effective concentration (EC\n                      <jats:sub>50<\/jats:sub>\n                      ) of compounds\n                      <jats:bold>7c<\/jats:bold>\n                      (0.264\u2009\u03bcg\/mL) and\n                      <jats:bold>7d<\/jats:bold>\n                      (0.436\u2009\u03bcg\/mL) were significantly lower than fluxapyroxad (EC\n                      <jats:sub>50<\/jats:sub>\n                      \u2009=\u20090.557\u2009\u03bcg\/mL). It is noteworthy that the median inhibitory concentration (IC\n                      <jats:sub>50<\/jats:sub>\n                      ) values of compounds\n                      <jats:bold>7c<\/jats:bold>\n                      and\n                      <jats:bold>7d<\/jats:bold>\n                      against succinate dehydrogenase (SDH) were 0.535 and 0.798\u2009\u03bcg\/mL, respectively, which were also substantially lower than fluxapyroxad (IC\n                      <jats:sub>50<\/jats:sub>\n                      \u2009=\u20090.891\u2009\u03bcg\/mL). And the inhibitory activities of compounds\n                      <jats:bold>7c<\/jats:bold>\n                      and\n                      <jats:bold>7d<\/jats:bold>\n                      against SDH were also further verified through fluorescence quenching. Finally, molecular docking was employed to simulate the interaction mechanisms of compounds\n                      <jats:bold>7c<\/jats:bold>\n                      and fluxapyroxad, with binding energies of compounds\n                      <jats:bold>7c<\/jats:bold>\n                      (\u221210.4\u2009kcal\/mol),\n                      <jats:bold>7d<\/jats:bold>\n                      (\u22128.2\u2009kcal\/mol) and positive control (\u22127.9\u2009kcal\/mol), respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>\n                      These results clearly confirmed that compounds\n                      <jats:bold>7c<\/jats:bold>\n                      and\n                      <jats:bold>7d<\/jats:bold>\n                      as structurally novel succinate dehydrogenase inhibitors (SDHIs) not only exhibit outstanding antifungal activity but also demonstrate potential value in overcoming critical issues such as drug resistance, presenting broad prospects for research and development. \u00a9 2026 Society of Chemical Industry.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ps.70594","type":"journal-article","created":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T06:25:07Z","timestamp":1769667907000},"page":"4792-4806","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Design, synthesis, antifungal activity and molecular docking studies of novel oxime ester amide derivatives"],"prefix":"10.1002","volume":"82","author":[{"given":"Min","family":"Liu","sequence":"first","affiliation":[{"name":"College of Materials and Chemical Engineering, Yibin University, A Key Lab of Process Analysis and Control of Sichuan Universities  Yibin P. 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