{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T18:36:52Z","timestamp":1787510212003,"version":"build-2736575974"},"reference-count":32,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T00:00:00Z","timestamp":1770595200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T00:00:00Z","timestamp":1770595200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFD1400400"],"award-info":[{"award-number":["2023YFD1400400"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32360687"],"award-info":[{"award-number":["32360687"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pest Management Science"],"published-print":{"date-parts":[[2026,6]]},"abstract":"Abstract<\/jats:title>\n \n BACKGROUND<\/jats:title>\n Plant\u2010parasitic nematodes (PPNs) pose a serious threat to global agricultural productivity. Most of the currently available nematicides have limitations in terms of efficacy and environmental safety. Therefore, there is an urgent need to discover new, highly effective and environmentally friendly nematicides.<\/jats:p>\n <\/jats:sec>\n \n RESULTS<\/jats:title>\n \n A series of thiazole derivatives were designed and synthesized through a scaffold\u2010hopping strategy. Some of these compounds exhibited excellent nematicidal activity. Compound\n \n A1<\/jats:bold>\n <\/jats:styled-content>\n displayed remarkable toxicity against\n Bursaphelenchus xylophilus<\/jats:italic>\n ,\n Aphelenchoides besseyi<\/jats:italic>\n , and\n Meloidogyne incognita<\/jats:italic>\n with median lethal concentration (\n \n LC\n 50<\/jats:sub>\n <\/jats:styled-content>\n ) values of 4.3, 1.9, and 6.2\u2009mg\/L, respectively, outperforming the commercial nematicide tioxazafen. Mechanistic studies revealed that compound\n \n A1<\/jats:bold>\n <\/jats:styled-content>\n effectively inhibited nematode egg hatching, induced excessive accumulation of reactive oxygen species (\n ROS<\/jats:styled-content>\n ), and caused vacuolization in nematode tissues. Pot experiments demonstrated that compound\n \n A1<\/jats:bold>\n <\/jats:styled-content>\n not only reduced nematode invasion but also enhanced the root defense response of tomato plants. Moreover, compound\n \n A1<\/jats:bold>\n <\/jats:styled-content>\n significantly inhibited succinate dehydrogenase (\n SDH<\/jats:styled-content>\n ) activity in\n M. incognita<\/jats:italic>\n , suggesting that interference with mitochondrial energy metabolism may contribute to its nematicidal effect.\n <\/jats:p>\n <\/jats:sec>\n \n CONCLUSION<\/jats:title>\n \n Thiazole\u2010based compound\n A1<\/jats:bold>\n can serve as an excellent lead compound from which new nematicides can be discovered through structural optimization in the future. \u00a9 2026 Society of Chemical Industry.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/ps.70644","type":"journal-article","created":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T07:31:54Z","timestamp":1770708714000},"page":"5376-5388","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Design, synthesis, nematicidal activity, and preliminary mechanism of thiazole derivatives through the scaffold hopping strategy"],"prefix":"10.1002","volume":"82","author":[{"given":"Zongnan","family":"Zhu","sequence":"first","affiliation":[{"name":"State Key Laboratory of Green Pesticide Center for R&D of Fine Chemicals of Guizhou University Guiyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyu","family":"Lu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Green Pesticide Center for R&D of Fine Chemicals of Guizhou University Guiyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4070-0824","authenticated-orcid":false,"given":"Xiuhai","family":"Gan","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Green Pesticide Center for R&D of Fine Chemicals of Guizhou University Guiyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenchao","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of 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