{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T06:06:31Z","timestamp":1778911591520,"version":"3.51.4"},"reference-count":42,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T00:00:00Z","timestamp":1770854400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T00:00:00Z","timestamp":1770854400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFD1700700"],"award-info":[{"award-number":["2023YFD1700700"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pest Management Science"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>WML\u201001, developed by our team, is a butenolide compound incorporating a thiazolidone structure, and shows excellent inhibitory activity against various pathogens in agriculture and other fields. However, little is known of its inhibition spectrum, protective and curative activity, and systemic translocation in plants.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULT<\/jats:title>\n                    <jats:p>\n                      This study evaluated the antimicrobial spectrum of WML\u201001, its effects on\n                      <jats:italic>Fusarium graminearum<\/jats:italic>\n                      development and deoxynivalenol (DON) production, protective and curative efficacy against Fusarium head blight (FHB), and systemic translocation in wheat. The compound exhibited selective inhibitory activity against 52 important plant pathogenic fungi and oomycetes, with potent activity against pathogens such as\n                      <jats:italic>Fusarium spp.<\/jats:italic>\n                      ,\n                      <jats:italic>Colletotrichum spp.<\/jats:italic>\n                      , and\n                      <jats:italic>Magnaporthe oryzae<\/jats:italic>\n                      , but negligible inhibition against oomycetes or basidiomycetes. WML\u201001 also significantly inhibited various developmental stages of\n                      <jats:italic>F. graminearum<\/jats:italic>\n                      , with EC\n                      <jats:sub>50<\/jats:sub>\n                      values of 0.0480\u2009\u03bcg\u2009mL\n                      <jats:sup>\u22121<\/jats:sup>\n                      for mycelial growth, 0.0054\u2009\u03bcg\u2009mL\n                      <jats:sup>\u22121<\/jats:sup>\n                      for conidiation, 0.1857\u2009\u03bcg\u2009mL\n                      <jats:sup>\u22121<\/jats:sup>\n                      for germ\u2010tube elongation, and 4.5651\u2009\u03bcg\u2009mL\n                      <jats:sup>\u22121<\/jats:sup>\n                      for conidial germination. WML\u201001 could also decrease DON production by\n                      <jats:italic>F. graminearum<\/jats:italic>\n                      . Under greenhouse conditions, WML\u201001 at 200\u2009mg\u2009L\n                      <jats:sup>\u22121<\/jats:sup>\n                      provided protective efficacy (72.61%) and curative efficacy (53.86%) against FHB, which was comparable to the control fungicide phenamacril (71.29% protective; 60.82% curative). High Performance Liquid Chromatography (HPLC) analysis confirmed the systemic translocation of WML\u201001 within wheat plants.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>The findings of this study demonstrate that WML\u201001 represents a promising novel fungicide, particularly for the control of FHB. Hence, it warrants further investigation and development. \u00a9 2026 Society of Chemical Industry.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ps.70655","type":"journal-article","created":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T05:14:20Z","timestamp":1770959660000},"page":"5497-5505","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Biological activity against plant pathogens and systemic translocation in wheat of\n                    <scp>WML<\/scp>\n                    \u201001, a spirocyclic butenolide derivative featuring a rhodanine motif"],"prefix":"10.1002","volume":"82","author":[{"given":"Ling","family":"Zhang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Crop Stress Resistance and High\u2010Efficiency Production, College of Plant Protection Northwest A&amp;F University  Yangling China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haoran","family":"Wu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Crop Stress Resistance and High\u2010Efficiency Production, College of Plant Protection Northwest A&amp;F University  Yangling China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinxin","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Crop Stress Resistance and High\u2010Efficiency Production, College of Plant Protection Northwest A&amp;F University  Yangling China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4683-6933","authenticated-orcid":false,"given":"Jianqiang","family":"Miao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Crop Stress Resistance and High\u2010Efficiency Production, College of Plant Protection Northwest A&amp;F University  Yangling China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3852-0672","authenticated-orcid":false,"given":"Mingan","family":"Wang","sequence":"additional","affiliation":[{"name":"Innovation Center of Pesticide Research, Department of Applied Chemistry College of Science, China Agricultural University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xili","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Crop Stress Resistance and High\u2010Efficiency Production, College of Plant Protection Northwest A&amp;F University  Yangling China"},{"name":"Department of Plant Pathology College of Plant Protection, China Agricultural University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,2,12]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cropro.2015.02.025"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-83402-7"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-019-0425-8"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10658-018-1471-2"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1094\/PDIS-03-12-0291-FE"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00253-011-3397-x"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mycres.2007.06.008"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodcont.2023.110027"},{"key":"e_1_2_8_10_1","first-page":"12","article-title":"Contamination and biotransformation of deoxynivalenol (DON) in common commercial foods: current status, challenges and future perspectives","volume":"6","author":"Zhao X","year":"2025","journal-title":"Green Synth Catal"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1094\/PDIS-04-18-0565-RE"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1094\/PDIS-02-19-0391-RE"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1094\/MPMI-22-9-1143"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/1462-2920.14874"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/jph.13021"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.5c02836"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/ps.6795"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pestbp.2022.105101"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pestbp.2024.105815"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1671-2927(11)60191-0"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2020.122908"},{"key":"e_1_2_8_22_1","unstructured":"WangM LiY ZhangTandZhangQ Butene lactone compound containing thiazolidone structure as well as preparation method and application thereof. 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