{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T13:14:43Z","timestamp":1788614083933,"version":"build-2803163510"},"reference-count":35,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,2,15]],"date-time":"2026-02-15T00:00:00Z","timestamp":1771113600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,15]],"date-time":"2026-02-15T00:00:00Z","timestamp":1771113600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pest Management Science"],"published-print":{"date-parts":[[2026,6]]},"abstract":"Abstract<\/jats:title>\n \n BACKGROUND<\/jats:title>\n \n Natural products and their synthetic derivatives are notable sources for discovering new lead compounds of herbicides. Terpene natural product (\n 3E<\/jats:styled-content>\n )\u20104, 8\u2010dimethyl\u20101, 3, 7\u2010nontriene (\n DMNT<\/jats:styled-content>\n ) has been proven to be able to repel and kill the insects, whereas its other bioactivities have rarely been studied.\n <\/jats:p>\n <\/jats:sec>\n \n RESULTS<\/jats:title>\n \n In this study, we focus on the herbicidal activity of\n DMNT<\/jats:styled-content>\n and its derivatives. A series of oxygen\u2010 or nitrogen\u2010containing\n DMNT<\/jats:styled-content>\n allyl derivatives were designed and synthesized as novel herbicide candidates. They were characterized by\n \n 1<\/jats:sup>\n H NMR\n <\/jats:styled-content>\n ,\n \n 13<\/jats:sup>\n C NMR\n <\/jats:styled-content>\n and\n HRMS<\/jats:styled-content>\n spectral analysis. Compared to\n DMNT<\/jats:styled-content>\n , the herbicidal activities of its derivatives were generally enhanced against monocotyledonous (\n Echinochloa crus\u2010galli<\/jats:italic>\n ,\n Lolium perenne<\/jats:italic>\n L.) and dicotyledonous weeds (\n Portulaca oleracea<\/jats:italic>\n L.,\n Abutilon theophrasti Medicus<\/jats:italic>\n ). Particularly, the\n DMNT<\/jats:styled-content>\n hydroxylation product (\n DMNT<\/jats:styled-content>\n \u2010\n OH<\/jats:styled-content>\n ,\n 2<\/jats:bold>\n ) completely inhibited the germination of\n E. crus\u2010galli<\/jats:italic>\n at 300\u2009mg\/L in the Petri dish assay, and also showed good herbicidal activity against the growth of weeds in the greenhouse test. Furthermore, it exhibited excellent crop safety for peanuts, wheat, rice and maize even at a dosage up to 2000\u2009g\/hm\n 2<\/jats:sup>\n . Ultimately, to further demonstrate the structural specificity and superior activity of\n DMNT<\/jats:styled-content>\n \u2010\n OH<\/jats:styled-content>\n , its herbicidal activity was comparatively analyzed with geraniol and geranial.\n <\/jats:p>\n <\/jats:sec>\n \n CONCLUSION<\/jats:title>\n These findings suggested that the herbicidal activity of DMNT significantly enhanced after structural modification, and DMNT\u2010OH has great potential as environmentally\u2010friendly herbicide candidate for further development. This study lays the basis for the exploration of DMNT as a botanical herbicide. \u00a9 2026 Society of Chemical Industry.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/ps.70658","type":"journal-article","created":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T07:00:06Z","timestamp":1771225206000},"page":"5506-5514","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Discovery of novel (\n 3E<\/scp>\n )\u20104, 8\u2010dimethyl\u20101, 3, 7\u2010nontriene skeleton analogues as potential herbicide candidates"],"prefix":"10.1002","volume":"82","author":[{"given":"Zhixuan","family":"Chen","sequence":"first","affiliation":[{"name":"School of Life Sciences Anhui Agricultural University Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Wen","sequence":"additional","affiliation":[{"name":"School of Life Sciences Anhui Agricultural University Hefei 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