{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T12:59:06Z","timestamp":1789909146078,"version":"4.0.1"},"reference-count":39,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T00:00:00Z","timestamp":1771286400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T00:00:00Z","timestamp":1771286400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pest Management Science"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>Addressing escalating pesticide resistance and food security necessitates sustainable plant pathogen management. This study rationally designed and synthesized novel chromone\u2010acylhydrazone derivatives engineered to target fungal tubulin, aiming to provide new avenues for disease control.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      We successfully designed and synthesized a series of novel chromone\u2010acylhydrazone derivatives. Compound H9 emerged as a highly potent lead, exhibiting remarkable inhibitory activity against\n                      <jats:italic>Sclerotinia sclerotiorum<\/jats:italic>\n                      with an EC\n                      <jats:sub>50<\/jats:sub>\n                      of 0.23\u2009\u03bcg\u2009mL\n                      <jats:sup>\u22121<\/jats:sup>\n                      . Mechanistic studies revealed that H9's 3\u2010fluorobenzoylhydrazide moiety disrupts microtubule polymerization via critical hydrogen bonding, while the chromone core facilitates favorable \u03c0\u2010alkyl interactions. H9 demonstrated promising pharmacokinetic profiles and negligible mammalian toxicity. Further, encapsulation within polyurethane microcapsules (H9\u2010Loaded PU MCs) yielded an efficient (89.12% encapsulation efficiency) sustained\u2010release system, significantly improving foliar adhesion and fungicidal efficacy.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>This work highlights H9 as a groundbreaking, safe fungicide, whose exceptional bioactivity, favorable safety profile, and advanced sustained\u2010release formulation technology offer a powerful solution for next\u2010generation sustainable pest management. This underscores the significant potential of rational molecular design coupled with advanced formulation technology in advancing pesticide candidates with green potential. \u00a9 2026 Society of Chemical Industry.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ps.70666","type":"journal-article","created":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T02:55:26Z","timestamp":1771383326000},"page":"5623-5636","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Revolutionizing anti\u2010fungal strategies: novel Chromone\u2010based microtubulin target fungicides for\n                    <scp>\n                      <i>Sclerotinia Sclerotiorum<\/i>\n                    <\/scp>\n                    of oilseed 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