{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T06:06:41Z","timestamp":1778911601458,"version":"3.51.4"},"reference-count":42,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T00:00:00Z","timestamp":1771459200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T00:00:00Z","timestamp":1771459200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100010226","name":"Department of Education of Guangdong Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pest Management Science"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>Pyrethroids based on chrysanthemic acid are widely used for mosquito control due to their high potency and low mammalian toxicity. However, growing resistance and environmental concerns necessitate new analogues. This study designed novel polyfluorinated pyrethroids derived from chrysanthemic acid scaffolds to overcome resistance, reduce ecotoxicity, and improve photostability.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Fourteen of 54 synthesized chrysanthemate\u2010based compounds exceeded bifenthrin (LC\n                      <jats:sub>50<\/jats:sub>\n                      \u2009=\u20091.96\u2009mg\/L) against sensitive mosquitoes. Lead compounds\n                      <jats:bold>BFA\u20103\u20101<\/jats:bold>\n                      ,\n                      <jats:bold>BFA\u20103\u20102<\/jats:bold>\n                      , and\n                      <jats:bold>BFA\u20103\u20104<\/jats:bold>\n                      showed LC\n                      <jats:sub>50<\/jats:sub>\n                      values of 0.55, 0.45, and 0.53\u2009mg\/L, respectively, and were 5\u20137 times more potent against resistant strains than deltamethrin. They also exhibited 10\u2010fold lower acute toxicity to zebrafish (96\u2009h\u2010LC\u2085\u2080\u2009=\u20090.47\u20130.67\u2009mg\/L) and longer photodegradation half\u2010lives (108\u2013133\u2009min under simulated sunlight).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>Chrysanthemic acid\u2010based polyfluorinated pyrethroids effectively break resistance, reduce non\u2010target toxicity, and maintain photostability, offering a sustainable chemical template for next\u2010generation vector control. \u00a9 2026 Society of Chemical Industry.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ps.70675","type":"journal-article","created":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T02:58:21Z","timestamp":1771556301000},"page":"5734-5744","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Rational design and multidimensional profiling of polyfluorinated pyrethroids: a resistance\u2010breaking strategy for next\u2010generation mosquito vector control"],"prefix":"10.1002","volume":"82","author":[{"given":"Xiaofang","family":"Li","sequence":"first","affiliation":[{"name":"School of Pharmacy and Food Engineering, Guangdong Provincial Key Laboratory of Large Animal Models for Biomedicine Wuyi University  Jiangmen People Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liwen","family":"Lei","sequence":"additional","affiliation":[{"name":"School of Pharmacy and Food Engineering, Guangdong Provincial Key Laboratory of Large Animal Models for Biomedicine Wuyi University  Jiangmen People Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xu","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Pharmacy and Food Engineering, Guangdong Provincial Key Laboratory of Large Animal Models for Biomedicine Wuyi University  Jiangmen People Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaowen","family":"Tang","sequence":"additional","affiliation":[{"name":"School of Pharmacy and Food Engineering, Guangdong Provincial Key Laboratory of Large Animal Models for Biomedicine Wuyi University  Jiangmen People Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2497-9631","authenticated-orcid":false,"given":"Song","family":"Ang","sequence":"additional","affiliation":[{"name":"School of Pharmacy and Food Engineering, Guangdong Provincial Key Laboratory of Large Animal Models for Biomedicine Wuyi University  Jiangmen People Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kun","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Pharmacy and Food Engineering, Guangdong Provincial Key Laboratory of Large Animal Models for Biomedicine Wuyi University  Jiangmen People Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dongli","family":"Li","sequence":"additional","affiliation":[{"name":"School of Pharmacy and Food Engineering, Guangdong Provincial Key Laboratory of Large Animal Models for Biomedicine Wuyi University  Jiangmen People Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weiqian David","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of Liverpool  Liverpool UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-5374-0427","authenticated-orcid":false,"given":"Panpan","family":"Wu","sequence":"additional","affiliation":[{"name":"School of Pharmacy and Food Engineering, Guangdong Provincial Key Laboratory of Large Animal Models for Biomedicine Wuyi University  Jiangmen People Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,2,19]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lanmic.2025.101073"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13071-024-06438-8"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(19)30161-6"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2022.05.012"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2022.120952"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.agee.2020.107253"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.etap.2019.103308"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2019.03.025"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10311-018-00852-y"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/plants12234022"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.3c01839"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/insects11080529"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/insects7040060"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1127\/entomologia\/2023\/2010"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-88121-x"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0012768"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.est.3c02716"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpc.2020.108758"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2024.119267"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pestbp.2021.104871"},{"key":"e_1_2_8_22_1","first-page":"113","article-title":"Chapter there\u2010neurotoxicology of pyrethroid insecticides","volume":"174","author":"Soderlund DM","year":"2020","journal-title":"Adv Neurotoxicol"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.3390\/insects14090767"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf102256s"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0149738"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13071-021-05095-5"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actatropica.2011.04.004"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2019.0802"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/ps.4916"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13071-024-06579-w"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40249-019-0605-x"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-63086-5"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2019.124604"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2021.127223"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2022.135426"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2020.122521"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26133811"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1093\/jee\/tox249"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf103908d"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0007432"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pestbp.2017.01.008"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1080\/01647954.2021.1914158"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.2174\/0929867323666161216143844"}],"container-title":["Pest Management Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/scijournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ps.70675","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/scijournals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ps.70675","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/scijournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ps.70675","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T05:08:25Z","timestamp":1778908105000},"score":1,"resource":{"primary":{"URL":"https:\/\/scijournals.onlinelibrary.wiley.com\/doi\/10.1002\/ps.70675"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,19]]},"references-count":42,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1002\/ps.70675"],"URL":"https:\/\/doi.org\/10.1002\/ps.70675","archive":["Portico"],"relation":{},"ISSN":["1526-498X","1526-4998"],"issn-type":[{"value":"1526-498X","type":"print"},{"value":"1526-4998","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,19]]},"assertion":[{"value":"2025-05-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-05","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}