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Plant immune inducers provide an effective strategy for controlling bacterial wilt disease.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>This study demonstrated a natural\u2010derived compound esculetin (ES) serves as a novel plant immune inducer against tobacco bacterial wilt. Foliar application of ES exhibits considerable control effect on tobacco bacterial wilt, with control efficacy is high as 45.41%\u201368.69%, significantly higher than positive control treatment\u2010benzothiadiazole (BTH). ES activates systemic acquired resistance (SAR) by upregulating transcriptional level of pathogenesis\u2010related (PR) genes, inducing reactive oxygen species (ROS) burst, enhancing defense\u2010related enzyme activity and salicylic acid (SA) accumulation. Transcriptomic analyses reveal that ES induces expression of mitogen\u2010activated protein kinase (MAPK) signaling pathways, SA biosynthesis, phenylpropanoid pathway and brassinosteroid biosynthesis pathway. Furthermore, ES confers broad\u2010spectrum resistance against other diseases like tobacco target spot, tobacco mosaic virus (TMV), wildfire disease and tobacco black shank.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>\n                      The study reveals a novel plant immunity inducer ES that confers broad\u2010spectrum resistance against\n                      <jats:italic>R. solanacearum<\/jats:italic>\n                      by activating the SA\u2010mediated SAR pathway, which provides a sustainable application of ES on bacterial wilt and other plant diseases in the future. \u00a9 2026 Society of Chemical Industry.\n                    <\/jats:p>\n                  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