{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T14:02:51Z","timestamp":1789826571047,"version":"4.0.1"},"reference-count":62,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T00:00:00Z","timestamp":1772668800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T00:00:00Z","timestamp":1772668800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pest Management Science"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>\n                      <jats:italic>Botrytis cinerea<\/jats:italic>\n                      , a highly destructive fungal pathogen with a broad host range, inflicts massive pre\u2010 and post\u2010harvest losses on crops like tomatoes and blueberries, endangering global agricultural sustainability and food security. Escalating pesticide resistance reduces the efficacy of conventional fungicides, creating an urgent need for novel, efficient, low\u2010toxicity antifungal agents. 1,3,4\u2010oxadiazole derivatives possess diverse bioactivities, making them ideal candidates for development.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Thirty novel 1,3,4\u2010oxadiazole derivatives were rationally designed via scaffold hopping and active substructure splicing.\n                      <jats:italic>In vitro<\/jats:italic>\n                      and\n                      <jats:italic>in vivo<\/jats:italic>\n                      assays showed compound R30 had the best antifungal activity, targeting lanosterol 14\u03b1\u2010demethylase to inhibit ergosterol synthesis, disrupting cell membranes, and inducing hyphal deformation. It exhibits favorable ADME properties, low toxicity to HaCaT\/HSF cells (IC\n                      <jats:sub>50<\/jats:sub>\n                      \u2009&gt;\u2009200\u2009\u03bcM).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>\n                      Compound R30 is a promising lead for efficient, low\u2010toxicity antifungal pesticides against\n                      <jats:italic>B. cinerea<\/jats:italic>\n                      . This study validates the adopted design strategy, enriches the structural diversity of ergosterol synthesis inhibitors, and provides valuable insights for sustainable control of fungal diseases and pesticide resistance. \u00a9 2026 Society of Chemical Industry.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ps.70707","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T13:44:53Z","timestamp":1772977493000},"page":"6256-6271","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Design, synthesis and antifungal activity of novel 1,3,4\u2010Oxadiazole derivatives against\n                    <scp>\n                      <i>Botrytis cinerea<\/i>\n                    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