{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T00:43:37Z","timestamp":1792629817607,"version":"4.5.0"},"reference-count":33,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T00:00:00Z","timestamp":1775692800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T00:00:00Z","timestamp":1775692800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pest Management Science"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>\n                      Plant diseases have long posed a severe threat to global agricultural production. Among these, kiwifruit canker and citrus canker\u2014caused by\n                      <jats:italic>Pseudomonas syringae<\/jats:italic>\n                      pv.\n                      <jats:italic>actinidiae<\/jats:italic>\n                      (\n                      <jats:italic>Psa<\/jats:italic>\n                      ) and\n                      <jats:italic>Xanthomonas axonopodis<\/jats:italic>\n                      pv.\n                      <jats:italic>citri<\/jats:italic>\n                      (\n                      <jats:italic>Xac<\/jats:italic>\n                      ), respectively\u2014are quarantine diseases that lack effective green control agents.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      This work synthesized novel berberine\u2013thioether derivatives, most of which showed potent antibacterial activity against\n                      <jats:italic>Psa<\/jats:italic>\n                      and\n                      <jats:italic>Xac<\/jats:italic>\n                      . The half\u2010effective concentration values of compounds B\u20104 \u2013 B\u20106 against\n                      <jats:italic>Xac<\/jats:italic>\n                      (0.29, 0.37, and 0.39\u2009\u03bcg\u2009mL\n                      <jats:sup>\u22121<\/jats:sup>\n                      , respectively) and of A\u20101 \u2013 A\u20106 against\n                      <jats:italic>Psa<\/jats:italic>\n                      (6.54, 3.98, 0.33, 0.36, 0.29, and 3.37\u2009\u03bcg\u2009mL\n                      <jats:sup>\u22121<\/jats:sup>\n                      , respectively) are markedly lower than those of berberine and thiodiazole\u2010copper (a commercial drug). Notably, compounds A\u20104 and B\u20104 can alter biofilm formation, increase reactive oxygen species levels, disrupt bacterial morphology, interact with DNA, and induce bacterial necrosis. Compound A\u20104 exhibits effective control activity against kiwifruit canker, with average protective and curative efficiency of 71.39% and 61.60%, respectively. Both compounds also showed great protective activity against citrus canker.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>\n                      In summary, we reported novel berberine\u2013thioether derivatives that demonstrate promising antibacterial activity against\n                      <jats:italic>Psa<\/jats:italic>\n                      and\n                      <jats:italic>Xac<\/jats:italic>\n                      . Their natural product origin and efficacy position them as potential lead compounds for managing plant bacterial canker diseases. \u00a9 2026 Society of Chemical Industry.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ps.70715","type":"journal-article","created":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T03:52:32Z","timestamp":1775793152000},"page":"6319-6330","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Unlocking the antibacterial potential of berberine\u2013thioether derivatives against plant canker"],"prefix":"10.1002","volume":"82","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8315-0092","authenticated-orcid":false,"given":"Mei","family":"Zhu","sequence":"first","affiliation":[{"name":"Department of Light Industry and Chemical Engineering Guizhou Light Industry Polytechnic University  Guiyang 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