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The worldwide problem of insecticide resistance prompted the search for novel targets and \u2018lead\u2019 insecticidal chemistries for these two species.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      The insecticidal activity and other biological effects of selected small molecules derived from an original random in\u2010house chemical library of 20\u2009000 compounds were investigated against mosquitoes. A multipronged approach included a cell\u2010based recombinant\n                      <jats:italic>Aedes<\/jats:italic>\n                      kinin receptor screen for potential antagonists, and the structure\u2013activity relationships. Out of the 88 small molecules investigated, seven kinin receptor full antagonists were identified, among which the small molecule SACC\u20100048555 was myoinhibitory of the mosquito hindgut contraction, increased female sugar\u2010feeding behavior, and potentiated mortality by malathion, all consistent with antagonism of the kinin system. Two identified structurally related molecules, SACC\u20100039590 and SACC\u20100428788, were not kinin receptor antagonists but were adulticidal for both mosquito species at sub\u2010micromolar levels when applied topically and through tarsal contact, and disrupted feeding when applied at a concentration that kills 25% of the tested population (LC\n                      <jats:sub>25<\/jats:sub>\n                      ).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>\n                      The activity of these small molecules, and their likely novel mode of action, offer a promising pathway for developing feeding stimulants for attractive targeted sugar baits and are chemical leads for future insecticide development. \u00a9 2026 The Author(s).\n                      <jats:italic>Pest Management Science<\/jats:italic>\n                      published by John Wiley &amp; Sons Ltd on behalf of Society of Chemical Industry.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ps.70764","type":"journal-article","created":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T02:50:04Z","timestamp":1775875804000},"page":"6842-6863","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Small molecules as arthropod kinin receptor antagonists, feeding modulators, or novel mosquitocidal agents"],"prefix":"10.1002","volume":"82","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0529-5269","authenticated-orcid":false,"given":"Bianca M.","family":"Henriques\u2010Santos","sequence":"first","affiliation":[{"name":"Department of Entomology Texas A&amp;M University  College Station TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7870-7266","authenticated-orcid":false,"given":"Patricia 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