{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T22:11:39Z","timestamp":1785190299082,"version":"3.55.0"},"reference-count":46,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T00:00:00Z","timestamp":1776211200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T00:00:00Z","timestamp":1776211200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pest Management Science"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>The poor stability and limited efficacy of biopesticides remain major bottlenecks restricting their widespread application. Herein, dual stimuli\u2010responsive kasugamycin (KAS) prodrug nanoparticles (DAS NPs) were constructed via self\u2010assembly by conjugating KAS with dialdehyde cellulose (DAC) through dynamic Schiff\u2010base bonds.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      The resulting DAS NPs exhibited a small particle size, negative zeta potential and low critical micelle concentration, which improved the wettability, photostability and dilution stability of the active ingredient on rice leaves.\n                      <jats:italic>In vitro<\/jats:italic>\n                      release experiments showed rapid responsiveness of DAS NPs to acidic pH and cellulase, leading to the cleavage of dynamic Schiff\u2010base bonds and controlled release of KAS. The nanosystem exhibited remarkable antifungal activity against rice blast in both glasshouse and field trials, effectively controlling the disease and prolonging the residual activity of KAS. Moreover, DAS NPs exhibited superior performance compared with the commercial KAS aqueous formulation in reducing rice yield losses caused by blast infection. Biological safety evaluations further confirmed excellent compatibility of DAS NPs with rice plants, aquatic organisms and soil ecosystems.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>This work provides field\u2010scale validation of DAS NPs via self\u2010assembly strategy, demonstrating substantial improvements in disease control efficacy, crop yield and grain quality. The dual stimuli\u2010responsive design improves pesticide utilization efficiency and offers an environmentally sustainable strategy for plant disease management. \u00a9 2026 Society of Chemical Industry.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ps.70807","type":"journal-article","created":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T04:00:13Z","timestamp":1776312013000},"page":"7404-7418","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["A biodegradable kasugamycin prodrug nanosystem for precise fungicide delivery and sustained disease control"],"prefix":"10.1002","volume":"82","author":[{"given":"You","family":"Liang","sequence":"first","affiliation":[{"name":"National Key Laboratory of Green Pesticide, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Center for Research and Development of Fine Chemicals Guizhou University  Guiyang 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