{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T16:51:54Z","timestamp":1787503914782,"version":"build-2736575974"},"reference-count":35,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T00:00:00Z","timestamp":1776297600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T00:00:00Z","timestamp":1776297600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32360687"],"award-info":[{"award-number":["32360687"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFD1400400"],"award-info":[{"award-number":["2023YFD1400400"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pest Management Science"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>Plant\u2010parasitic nematodes pose a severe threat to crops, causing over $175 billion in economic losses to global agriculture.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      To discover novel nematicides, a database of more than 2000 molecules was constructed, and several active scaffold structures were obtained through rapid\n                      <jats:italic>in vitro<\/jats:italic>\n                      nematicidal activity screening. Eight pyrimidine derivatives containing 1,2,4\u2010oxadiazole moieties were designed and synthesized using scaffold hopping strategies that grafted tioxazafen onto the active pyrimidine structure. Among the 38 pyrimidine compounds screened or synthesized, the majority exhibited excellent nematicidal activity. For example, compound D27 showed median lethal concentration (LC\n                      <jats:sub>50<\/jats:sub>\n                      ) values of 3.7\u2009mg\/L and 11.4\u2009mg\/L against\n                      <jats:italic>Meloidogyne incognita<\/jats:italic>\n                      and\n                      <jats:italic>Aphelenchoides besseyi<\/jats:italic>\n                      , respectively, significantly superior to the lead nematicide tioxazafen. Compound D27 exhibited excellent\n                      <jats:italic>in vivo<\/jats:italic>\n                      nematocidal activity against\n                      <jats:italic>M. incognita<\/jats:italic>\n                      in tomatoes (93.3%) at 50\u2009mg\/L, which was significantly superior to the positive control tioxazafen (45.3%). Compound D27 not only induced significant oxidative stress adverse reactions in nematodes, but also decreased the frequency of head swinging and inhibited their egg\u2010hatching capacity. In addition, compound D3 significantly inhibits the feeding and reproductive capacity of\n                      <jats:italic>Bursaphelenchus xylophilus<\/jats:italic>\n                      , affects the activity of defense enzymes (superoxide dismutase, peroxidase, and catalase) within the organism, and inhibits the activity of the succinate dehydrogenase enzyme.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>This scaffold can serve as the core structure for discovery of novel nematicides. We continue to optimize this scaffold structure, aiming to discover highly effective novel nematicides in future research. \u00a9 2026 Society of Chemical Industry.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ps.70810","type":"journal-article","created":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T04:17:47Z","timestamp":1776399467000},"page":"7434-7448","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Design, synthesis, nematicidal activity, and preliminary mechanism of pyrimidine derivatives through the scaffold hopping strategy"],"prefix":"10.1002","volume":"82","author":[{"given":"Tingting","family":"Du","sequence":"first","affiliation":[{"name":"State Key Laboratory of Green Pesticide Center for R&amp;D of Fine Chemicals of Guizhou University  Guiyang 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