{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T08:08:12Z","timestamp":1783843692986,"version":"3.55.0"},"reference-count":62,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T00:00:00Z","timestamp":1778025600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T00:00:00Z","timestamp":1778025600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005046","name":"Natural Science Foundation of Heilongjiang Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005046","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pest Management Science"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>The escalating resistance of phytopathogenic fungi to conventional fungicides, combined with increasing environmental concerns, necessitates the development of novel bioactive agents.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      In this study, utilizing the natural product quinine as a lead scaffold, a series of novel 2\u2010aminoquinine derivatives were designed and synthesized via PyBroP\u2010mediated amination. The antifungal activities of these compounds against seven plant pathogens, including\n                      <jats:italic>Rhizoctonia solani (R. solani)<\/jats:italic>\n                      ,\n                      <jats:italic>Cytospora chrysosperma (C. chrysosperma)<\/jats:italic>\n                      ,\n                      <jats:italic>Fusarium oxysporum (F. oxysporum)<\/jats:italic>\n                      ,\n                      <jats:italic>Magnaporthe oryzae (M. oryzae)<\/jats:italic>\n                      ,\n                      <jats:italic>Fusarium graminearum (F. graminearum)<\/jats:italic>\n                      ,\n                      <jats:italic>Sphaeropsis sapinea (S. sapinea)<\/jats:italic>\n                      , and\n                      <jats:italic>Botrytis cinerea (B. cinerea)<\/jats:italic>\n                      , were evaluated using the mycelial growth rate method. Among the synthesized derivatives, compound\n                      <jats:bold>Qed\u20103<\/jats:bold>\n                      exhibited broad\u2010spectrum efficacy, particularly against\n                      <jats:italic>S. sapinea<\/jats:italic>\n                      with a half\u2010maximal effective concentration (EC\n                      <jats:sub>50<\/jats:sub>\n                      ) value of 0.46\u2009\u03bcg\u2009mL\n                      <jats:sup>\u22121<\/jats:sup>\n                      .\n                      <jats:italic>In vivo<\/jats:italic>\n                      assays further confirmed its superior curative potential against pine shoot blight compared to the commercial fungicide boscalid. Mechanistic investigations, utilizing scanning electron microscopy (SEM) and transmission electron microscopy (TEM), revealed that compound\n                      <jats:bold>Qed\u20103<\/jats:bold>\n                      disrupts the integrity of hyphal cell walls and membranes, leading to electrolyte leakage and the accumulation of reactive oxygen species (ROS).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>Molecular docking and quantitative structure\u2013activity relationship (QSAR) analyses provided insights into the binding modes and structural determinants essential for antifungal potency. These findings highlight the potential of 2\u2010arylaminoquinine as a promising and eco\u2010friendly candidate for novel fungicide development. \u00a9 2026 Society of Chemical Industry.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ps.70820","type":"journal-article","created":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T04:40:43Z","timestamp":1778128843000},"page":"7575-7588","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Structural evolution of quinine derivatives for enhanced antifungal potency: key modifications and quantitative structure\u2013activity relationship (\n                    <scp>QSAR<\/scp>\n                    ) analysis"],"prefix":"10.1002","volume":"82","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-0237-0720","authenticated-orcid":false,"given":"Lihong","family":"Fan","sequence":"first","affiliation":[{"name":"College of Chemistry, Chemical Engineering and Resource Utilization, Northeast Forestry University  Harbin P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye","family":"Wu","sequence":"additional","affiliation":[{"name":"College of Chemistry, Chemical Engineering and Resource Utilization, Northeast Forestry University  Harbin P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yining","family":"Lei","sequence":"additional","affiliation":[{"name":"College of Chemistry, Chemical Engineering and Resource Utilization, Northeast Forestry University  Harbin P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yizhou","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Chemistry, Chemical Engineering and Resource Utilization, Northeast Forestry University  Harbin P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingxuan","family":"Li","sequence":"additional","affiliation":[{"name":"College of Chemistry, Chemical Engineering and Resource Utilization, Northeast Forestry University  Harbin P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunxia","family":"Chen","sequence":"additional","affiliation":[{"name":"College of Chemistry, Chemical Engineering and Resource Utilization, Northeast Forestry University  Harbin P. R. China"},{"name":"Center for Innovative Research in Synthetic Chemistry and Resource Utilization, Northeast Forestry University  Harbin P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-5671-1981","authenticated-orcid":false,"given":"Hanbao","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Chemistry, Chemical Engineering and Resource Utilization, Northeast Forestry University  Harbin P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lianxu","family":"Shi","sequence":"additional","affiliation":[{"name":"College of Chemistry, Chemical Engineering and Resource Utilization, Northeast Forestry University  Harbin P. R. China"},{"name":"Center for Innovative Research in Synthetic Chemistry and Resource Utilization, Northeast Forestry University  Harbin P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinsong","family":"Peng","sequence":"additional","affiliation":[{"name":"College of Chemistry, Chemical Engineering and Resource Utilization, Northeast Forestry University  Harbin P. R. China"},{"name":"Center for Innovative Research in Synthetic Chemistry and Resource Utilization, Northeast Forestry University  Harbin P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,6]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/d41586-023-01465-4"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00449-20"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nclimate3303"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1094\/PDIS-01-20-0084-RE"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/plcell\/koad118"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/jof7080607"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1128\/mSphere.00883-20"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsbiomedchemau.5c00103"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1094\/PHYTO-10-22-0370-KD"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.5c11544"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.8b00031"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr5003134"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.5c10117"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.5c05257"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.5c07227"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.4c10490"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.5c10514"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.4c01948"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1094\/PHYTO-01-24-0034-R"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.1c02616"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.17221\/17\/2023-PPS"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11101-025-10176-9"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1521-3757(19990517)111:10<1416::AID-ANGE1416>3.0.CO;2-O"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf048880e"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2875-10-144"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-023-00772-9"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2020.115973"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.5b01485"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.2174\/1389557521666210210155908"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-025-23347-7"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.9b04224"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.1c05677"},{"key":"e_1_2_8_34_1","first-page":"22524","article-title":"Design, synthesis, and biological evaluation of novel quinoline derivatives against phytopathogenic bacteria inspired from natural quinine alkaloids","volume":"72","author":"Qin LL","year":"2024","journal-title":"J Agric Food Chem"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.4c01582"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aac.2024.10.002"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24043383"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1021\/tx025674x"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3565(25)20010-6"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aac.2025.01.004"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aac.2025.10.005"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/8.3.275"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1093\/molbev\/msab120"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejoc.201900431"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1021\/ol102301u"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.5c02935"},{"key":"e_1_2_8_47_1","first-page":"170","article-title":"Identification and screening of fungicides of pathogen causing a new leaf blight disease in Pinus sylvestris var. mongholica","volume":"49","author":"Wu YY","year":"2025","journal-title":"J Nanjing For Univ (Nat Sci Ed)"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.2c03441"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.5c00617"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphotobiol.2012.02.001"},{"key":"e_1_2_8_51_1","volume-title":"GaussView, Version 6","author":"Dennington R","year":"2016"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.21707"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.23361"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.21334"},{"key":"e_1_2_8_55_1","volume-title":"The PyMOL Molecular Graphics System","author":"DeLano WL","year":"2002"},{"key":"e_1_2_8_56_1","volume-title":"Discovery Studio Modeling Environment","author":"Dassault Syst\u00e8mes BIOVIA","year":"2025"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1080\/00401706.1969.10490666"},{"key":"e_1_2_8_58_1","volume-title":"Molecular Descriptors for Chemoinformatics","author":"Fechner N","year":"2009"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1021\/ci00028a014"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1080\/1062936X.2011.569900"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2011.07.008"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.1111\/nph.12193"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.061562898"}],"container-title":["Pest Management Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/scijournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ps.70820","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/scijournals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ps.70820","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/scijournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ps.70820","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T07:41:57Z","timestamp":1783842117000},"score":1,"resource":{"primary":{"URL":"https:\/\/scijournals.onlinelibrary.wiley.com\/doi\/10.1002\/ps.70820"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,6]]},"references-count":62,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1002\/ps.70820"],"URL":"https:\/\/doi.org\/10.1002\/ps.70820","archive":["Portico"],"relation":{},"ISSN":["1526-498X","1526-4998"],"issn-type":[{"value":"1526-498X","type":"print"},{"value":"1526-4998","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,6]]},"assertion":[{"value":"2026-02-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-30","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}