{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T06:30:54Z","timestamp":1790231454537,"version":"4.1.0"},"reference-count":50,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T00:00:00Z","timestamp":1776729600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T00:00:00Z","timestamp":1776729600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32573387"],"award-info":[{"award-number":["32573387"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32273027"],"award-info":[{"award-number":["32273027"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pest Management Science"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>\n                      Fatty acid\u2010binding proteins (FABPs) play crucial roles in various physiological processes in arthropods and are considered promising targets for pest control. However, their functions and potential as vaccine candidates against\n                      <jats:italic>Dermanyssus gallinae<\/jats:italic>\n                      , a notorious hematophagous poultry pest, remain unexplored. This study aims to characterize a newly identified FABP in\n                      <jats:italic>D<\/jats:italic>\n                      .\n                      <jats:italic>gallinae<\/jats:italic>\n                      (designated as DgFABP), elucidate its physiological roles, and evaluate its potential as a candidate vaccine antigen.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      The DgFABP was localized in the testes, synganglion, cuticle, and midgut of male mites. RNA interference (RNAi) silencing of\n                      <jats:italic>DgFABP<\/jats:italic>\n                      significantly increased mortality in adult males (by 13.3%) and male deutonymphs (by 34.7%), while reducing the latter molting rate by 11.6%. Notably, the mating rate of individual males decreased by 60.0%, which consequently led to a significant reduction in the oviposition rate of the female in freely mating assays. Recombinant DgFABP (rDgFABP) induced strong antibody responses in chicks. This immune response resulted in a significant increase in the mortality rates of both male and female deutonymphs. Most importantly, the lowest oviposition rate (35.98\u2009\u00b1\u20092.13%) was observed when virgin females fed on immunized birds were mated with males who had fed on immunized chicks as deutonymphs.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>\n                      DgFABP is critical for the survival, molting, and reproductive success of\n                      <jats:italic>D<\/jats:italic>\n                      .\n                      <jats:italic>gallinae<\/jats:italic>\n                      . The significant reduction in reproductive ability and increased mite mortality following immunization highlights the strong potential of rDgFABP as a novel vaccine candidate for the sustainable control of poultry red mite infestations. \u00a9 2026 Society of Chemical Industry.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ps.70838","type":"journal-article","created":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T03:56:03Z","timestamp":1776830163000},"page":"7758-7767","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Fatty acid\u2010binding protein is essential for molting and male mating in\n                    <scp>\n                      <i>Dermanyssus gallinae<\/i>\n                    <\/scp>\n                    and confers protection as a vaccine antigen"],"prefix":"10.1002","volume":"82","author":[{"given":"Boxing","family":"Liu","sequence":"first","affiliation":[{"name":"State Key Laboratory of Veterinary Public Health Security, College of Veterinary Medicine China Agricultural University  Beijing China"},{"name":"Modern Dairy (Group) Co., Ltd  Maanshan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4421-206X","authenticated-orcid":false,"given":"Yuke","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Veterinary Public Health Security, College of Veterinary Medicine China Agricultural University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bohan","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Veterinary Public Health Security, College of Veterinary Medicine China Agricultural University  Beijing China"},{"name":"Beijing Vocational College of Agriculture  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Deng","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Veterinary Public Health Security, College of Veterinary Medicine China Agricultural University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Veterinary Public Health Security, College of Veterinary Medicine China Agricultural University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiwei","family":"Sun","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Veterinary Public Health Security, College of Veterinary Medicine China Agricultural University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baoliang","family":"Pan","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Veterinary Public Health Security, College of Veterinary Medicine China Agricultural University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,21]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13071-015-0768-7"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10493-023-00869-1"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13071-017-2292-4"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-ento-011613-162101"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpara.2008.09.006"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/vaccines7030121"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ps.6664"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1466252307001193"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-nutr-062220-112240"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-002-8490-y"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpc.2005.11.006"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0029576"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2760(90)90521-X"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1017\/S003118201000079X"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-010-0666-1"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-56690-2"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pestbp.2024.106044"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2015.10.027"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-15-518"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0004323"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetpar.2018.06.003"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetpar.2020.109246"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molp.2023.09.010"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1006\/meth.2001.1262"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pestbp.2024.105960"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2020.10.010"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetpar.2025.110405"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/jisesa\/ieu129"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetpar.2025.110411"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/jmedent\/25.5.321"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/arch.21001"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-2836(92)90501-A"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jia.2022.08.003"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11427-012-4274-2"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cris.2022.100039"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.plipres.2015.06.001"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10493-016-0103-9"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13592-013-0198-5"},{"key":"e_1_2_9_40_1","first-page":"137","article-title":"Mating disruption of the honeybee mite varroa destructo under laboratory and field conditions","volume":"24","author":"Ziegelmann B","year":"2014","journal-title":"Chem"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2583.2004.00548.x"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1673\/031.013.10101"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1098\/rsob.240254"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ibmb.2022.103845"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1618258113"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pestbp.2018.07.003"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-69449-6"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00436-005-1397-4"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.01022"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmor.1051500404"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/ps.7033"}],"container-title":["Pest Management Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/scijournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ps.70838","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/scijournals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ps.70838","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/scijournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ps.70838","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T07:44:56Z","timestamp":1783842296000},"score":1,"resource":{"primary":{"URL":"https:\/\/scijournals.onlinelibrary.wiley.com\/doi\/10.1002\/ps.70838"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,21]]},"references-count":50,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1002\/ps.70838"],"URL":"https:\/\/doi.org\/10.1002\/ps.70838","archive":["Portico"],"relation":{},"ISSN":["1526-498X","1526-4998"],"issn-type":[{"value":"1526-498X","type":"print"},{"value":"1526-4998","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,21]]},"assertion":[{"value":"2025-12-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}