{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,9]],"date-time":"2026-08-09T16:41:23Z","timestamp":1786293683703,"version":"build-2736575974"},"reference-count":45,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T00:00:00Z","timestamp":1778112000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T00:00:00Z","timestamp":1778112000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22277081"],"award-info":[{"award-number":["22277081"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pest Management Science"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>\n                      Asian soybean rust caused by\n                      <jats:italic>Phakopsora pachyrhizi<\/jats:italic>\n                      (\n                      <jats:italic>P. pachyrhizi<\/jats:italic>\n                      ) poses a serious threat to global soybean production, and resistance to conventional fungicides is increasing. Therefore, new fungicides with novel modes of action are urgently needed. This study aimed to design and optimize potent 5\u2010(trifluoromethyl)\u20101,2,4\u2010oxadiazole (TFMO) derivatives inspired by fungal histone deacetylase inhibition.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Forty\u2010two TFMO derivatives were synthesized through bioisosteric modification and linker optimization. Among them,\n                      <jats:bold>FM\u201017888<\/jats:bold>\n                      showed the highest activity against\n                      <jats:italic>P. pachyrhizi<\/jats:italic>\n                      , with an EC\n                      <jats:sub>50<\/jats:sub>\n                      value of 0.0583\u2009mg\u00b7L\n                      <jats:sup>\u22121<\/jats:sup>\n                      , approximately eightfold lower than that of flufenoxadiazam. Under the tested greenhouse conditions,\n                      <jats:bold>FM\u201017888<\/jats:bold>\n                      also showed good crop safety and selective activity against\n                      <jats:italic>Puccinia triticina<\/jats:italic>\n                      . Molecular docking and DFT analyses suggested that its improved activity may be associated with favorable binding geometry, additional\n                      <jats:italic>\u03c0<\/jats:italic>\n                      \u2010sulfur interactions, and a reduced HOMO\u2010LUMO energy gap.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>\n                      <jats:bold>FM\u201017888<\/jats:bold>\n                      is a potent and selective TFMO lead compound for soybean rust control. Together with the greenhouse bioassay, docking, and DFT results, these findings support\n                      <jats:bold>FM\u201017888<\/jats:bold>\n                      as a promising candidate for further development against rust diseases, while direct target\u2010validation studies are still needed to confirm its precise mode of action. \u00a9 2026 Society of Chemical Industry.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ps.70879","type":"journal-article","created":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T04:00:01Z","timestamp":1778212801000},"page":"8309-8318","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Novel histone deacetylase\u2010inhibiting 5\u2010(trifluoromethyl)\u20101,2,4\u2010oxadiazole derivatives with exceptional efficacy against\n                    <scp>\n                      <i>Phakopsora pachyrhizi<\/i>\n                    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Shenyang University of Chemical Technology  Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxin","family":"Huang","sequence":"additional","affiliation":[{"name":"National\u2010Local Joint Engineering Laboratory for Development of Boron and Magnesium Resources and Fine Chemical Technology, Liaoning Province Key Laboratory of Green Functional Molecular Design and Development, Shenyang Key Laboratory of Targeted Pesticides Institute of Functional Molecules, Shenyang University of Chemical Technology  Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-7872-8252","authenticated-orcid":false,"given":"Fanqi","family":"Meng","sequence":"additional","affiliation":[{"name":"National\u2010Local Joint Engineering Laboratory for Development of Boron and Magnesium Resources and Fine Chemical Technology, Liaoning Province Key Laboratory of Green Functional Molecular Design and Development, Shenyang Key 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