{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,9]],"date-time":"2026-08-09T16:41:09Z","timestamp":1786293669649,"version":"build-2736575974"},"reference-count":25,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,5,10]],"date-time":"2026-05-10T00:00:00Z","timestamp":1778371200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,10]],"date-time":"2026-05-10T00:00:00Z","timestamp":1778371200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22277081"],"award-info":[{"award-number":["22277081"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pest Management Science"],"published-print":{"date-parts":[[2026,9]]},"abstract":"Abstract<\/jats:title>\n \n BACKGROUND<\/jats:title>\n \n Asian soybean rust (ASR), caused by\n Phakopsora pachyrhizi<\/jats:italic>\n , remains difficult to control because resistance has reduced the effectiveness of several major fungicide classes. In this study, we designed 1,2,4\u2010oxadiazole derivatives bearing tetrazolinone or triazolinone fragments through fragment recombination and then explored the putative target\u2010binding characteristics of the lead compound by computational methods.\n <\/jats:p>\n <\/jats:sec>\n \n RESULTS<\/jats:title>\n \n Twenty\u2010four target compounds were synthesized and evaluated against\n P. pachyrhizi<\/jats:italic>\n ,\n Pseudoperonospora cubensis<\/jats:italic>\n ,\n Blumeria graminis<\/jats:italic>\n , and\n Corynespora cassiicola<\/jats:italic>\n . Among them, the triazolinone derivative\n B9<\/jats:bold>\n (FM\u20103224) showed the best overall performance. Against\n P. pachyrhizi<\/jats:italic>\n , FM\u20103224 gave an EC\n 50<\/jats:sub>\n of 0.82\u2009mg\u2009L\n \u22121<\/jats:sup>\n , compared with 2.65\u2009mg\u2009L\n \u22121<\/jats:sup>\n for flufenoxadiazam and 3.08\u2009mg\u2009L\n \u22121<\/jats:sup>\n for metyltetraprole. FM\u20103224 also showed strong activity against the other three pathogens. Docking analyses suggested favorable interactions of FM\u20103224 with HDAC\n 4<\/jats:sub>\n and the\n Saccharomyces cerevisiae<\/jats:italic>\n bc1 complex, and density functional theory (DFT) calculations indicated a relatively small HOMO\u2013LUMO gap (0.16815\u2009a.u.), suggesting comparatively favorable electronic responsiveness.\n <\/jats:p>\n <\/jats:sec>\n \n CONCLUSION<\/jats:title>\n FM\u20103224 is a promising broad\u2010spectrum lead compound. The biological results establish its strong fungicidal potential, whereas the docking and DFT analyses provide computational support for further investigation of its putative dual\u2010target binding mode. \u00a9 2026 Society of Chemical Industry.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/ps.70895","type":"journal-article","created":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T03:57:46Z","timestamp":1778471866000},"page":"8440-8447","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["FM<\/scp>\n \u20103224: A potent triazolinone\u2010based fungicide with broad\u2010spectrum activity and computational support for putative dual\u2010target binding"],"prefix":"10.1002","volume":"82","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-7872-8252","authenticated-orcid":false,"given":"Fanqi","family":"Meng","sequence":"first","affiliation":[{"name":"National\u2010Local Joint Engineering Laboratory for Development of Boron and Magnesium Resources and Fine Chemical Technology, Liaoning Province Key Laboratory of Green Functional Molecular Design and Development, Shenyang Key Laboratory of Targeted Pesticides Institute of Functional Molecules, Shenyang University of Chemical Technology Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuandong","family":"Liu","sequence":"additional","affiliation":[{"name":"National\u2010Local Joint Engineering Laboratory for Development of Boron and Magnesium Resources and Fine Chemical Technology, Liaoning Province Key Laboratory of Green Functional Molecular Design and Development, Shenyang Key Laboratory of Targeted Pesticides Institute of Functional Molecules, Shenyang University of Chemical Technology Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaowen","family":"Du","sequence":"additional","affiliation":[{"name":"National\u2010Local Joint Engineering Laboratory for Development of Boron and Magnesium Resources and Fine Chemical Technology, Liaoning Province Key Laboratory of Green Functional Molecular Design and Development, Shenyang Key Laboratory of Targeted Pesticides Institute of Functional Molecules, Shenyang University of Chemical Technology Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Tian","sequence":"additional","affiliation":[{"name":"National\u2010Local Joint Engineering Laboratory for Development of Boron and Magnesium Resources and Fine Chemical Technology, Liaoning Province Key Laboratory of Green Functional Molecular Design and Development, Shenyang Key Laboratory of Targeted Pesticides Institute of Functional Molecules, Shenyang University of Chemical Technology Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zhang","sequence":"additional","affiliation":[{"name":"National\u2010Local Joint Engineering Laboratory for Development of Boron and Magnesium Resources and Fine Chemical Technology, Liaoning Province Key Laboratory of Green Functional Molecular Design and Development, Shenyang Key Laboratory of Targeted Pesticides Institute of Functional Molecules, Shenyang University of Chemical Technology Shenyang China"},{"name":"Metisa Biotechnology Co., Ltd. Nanning China"},{"name":"School of Chemical Engineering, University of Science and Technology Liaoning Anshan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lixin","family":"Zhang","sequence":"additional","affiliation":[{"name":"National\u2010Local Joint Engineering Laboratory for Development of Boron and Magnesium Resources and Fine Chemical Technology, Liaoning Province Key Laboratory of Green Functional Molecular Design and Development, Shenyang Key Laboratory of Targeted Pesticides Institute of Functional Molecules, Shenyang University of Chemical Technology Shenyang China"},{"name":"Metisa Biotechnology Co., Ltd. Nanning China"},{"name":"School of Chemical Engineering, University of Science and Technology Liaoning Anshan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,10]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/tpg2.20109"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1364-3703.2009.00589.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms222111658"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00122-022-04168-y"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11696-022-02522-4"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12154-014-0113-1"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2023.115417"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ps.5874"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.4c09039"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/med.20024"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.5c08660"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/ps.5288"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ps.5697"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10327-022-01081-6"},{"key":"e_1_2_8_16_1","first-page":"488","article-title":"Synthesis and fungicidal activity of metyltetraprole","volume":"63","author":"Zhang A","year":"2024","journal-title":"Agrochemicals"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/chin.199019192"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2019.115211"},{"key":"e_1_2_8_19_1","unstructured":"GuW YangZH LiuQS SunY WangSF SunXBet al. Preparation method and application of 5\u2010trifluoromethyl substituted oxadiazole compound containing diphenyl ether group. 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