{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,9]],"date-time":"2026-08-09T16:41:17Z","timestamp":1786293677543,"version":"build-2736575974"},"reference-count":149,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T00:00:00Z","timestamp":1778544000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T00:00:00Z","timestamp":1778544000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pest Management Science"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The domesticated silkworm (\n                    <jats:italic>Bombyx mori<\/jats:italic>\n                    ) is an established model for investigating pesticide ecotoxicology in Lepidoptera. However, a systems\u2010level integration of its molecular response networks across diverse pesticide classes is still lacking. This review synthesizes multi\u2010omics, physiological, and biochemical data to construct a comprehensive framework for the toxicity of\n                    <jats:italic>B. mori<\/jats:italic>\n                    . Our analysis revealed that pesticide exposure universally disrupts energy homeostasis by inhibiting mitochondrial oxidative phosphorylation (OXPHOS) and dysregulating trehalose metabolism, culminating in severe ATP depletion. The resulting overproduction of ROS sequentially triggers major defense pathways, such as the PI3K\/Akt, MAPK\/CREB, and CncC\/Keap1 pathways. These pathways coordinate the transcriptional activation of antioxidant enzymes and detoxification proteins, including P450s, GSTs, and CarEs, via ARE\u2010 and XRE\u2010dependent mechanisms. Concurrently, pesticides induce autophagy\u2010apoptosis crosstalk via calcium dysregulation and caspase cascade activation. This molecular disruption is compounded by the reshaping of the gut microbiota, characterized by the enrichment of opportunistic pathogens, such as\n                    <jats:italic>Enterobacter<\/jats:italic>\n                    , and the depletion of beneficial symbionts, such as\n                    <jats:italic>Bifidobacterium<\/jats:italic>\n                    , alongside the suppression of Toll\/IMD\/JAK\u2013STAT immune signaling. This dual assault on immunity and metabolism creates a synergistic \u2018multi\u2010hit\u2019 effect that dramatically increases susceptibility to pathogens, such as BmNPV. This integrated framework identifies the CncC\u2010ARE axis, mitochondrial energy sensors, and gut microbiota\u2010host interactions as central regulatory hubs and promising targets for intervention. By translating these mechanistic insights from silkworms to broader lepidopteran pests, this study provides a theoretical foundation for ecological risk assessment and biomarker discovery. Furthermore, it establishes a roadmap for developing targeted green pest management strategies with direct implications for advancing sustainable sericulture and precision pest control. \u00a9 2026 Society of Chemical Industry.\n                  <\/jats:p>","DOI":"10.1002\/ps.70901","type":"journal-article","created":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T04:04:39Z","timestamp":1778645079000},"page":"8064-8090","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Beyond silkworms: translating molecular mechanisms of pesticide toxicity from\n                    <scp>\n                      <i>Bombyx mori<\/i>\n                    <\/scp>\n                    to lepidopteran pest management"],"prefix":"10.1002","volume":"82","author":[{"given":"Dan\u2010Dan","family":"Bian","sequence":"first","affiliation":[{"name":"College of Life Science and Agriculture Forestry Qiqihar University  Qiqihar 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China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2682-074X","authenticated-orcid":false,"given":"Bo\u2010Ping","family":"Tang","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory for Bioresources of Saline Soils, Jiangsu Synthetic Innovation Center for Coastal Bio\u2010agriculture, Jiangsu Provincial Key Laboratory of Coastal Wetland Bioresources and Environmental Protection, School of Wetlands Yancheng Teachers University  Yancheng China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9264-019X","authenticated-orcid":false,"given":"Qiu\u2010Ning","family":"Liu","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory for Bioresources of Saline Soils, Jiangsu Synthetic Innovation Center for Coastal Bio\u2010agriculture, Jiangsu Provincial Key Laboratory of Coastal Wetland Bioresources and Environmental Protection, School of Wetlands Yancheng Teachers 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