{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,9]],"date-time":"2026-08-09T16:41:11Z","timestamp":1786293671437,"version":"build-2736575974"},"reference-count":42,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T00:00:00Z","timestamp":1779840000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T00:00:00Z","timestamp":1779840000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pest Management Science"],"published-print":{"date-parts":[[2026,9]]},"abstract":"Abstract<\/jats:title>\n \n BACKGROUND<\/jats:title>\n \n Late blight caused by the oomycete\n Phytophthora infestans<\/jats:italic>\n remains one of the most devastating diseases threatening global potato and tomato production. Overuse of a narrow range of fungicides has sped up resistance, making it urgent to develop new agents that work differently and are safer.\n <\/jats:p>\n <\/jats:sec>\n \n RESULTS<\/jats:title>\n \n In this study, a series of\n N<\/jats:italic>\n \u2010aryloxyethyl heterocycles were rationally designed by integrating the aryloxyethyl scaffold of phenoxyethanol with bioactive heterocyclic frameworks. Among the 40 synthesized derivatives, compound\n 8c<\/jats:bold>\n exhibited the highest anti\u2010oomycete activity against\n P. infestans<\/jats:italic>\n , with an EC\n 50<\/jats:sub>\n value of 1.67\u2009mg\u2009L\n \u22121<\/jats:sup>\n . In potted tomato assays,\n 8c<\/jats:bold>\n provided over 90% protective and curative efficacy at 50\u2009mg\u2009L\n \u22121<\/jats:sup>\n , comparable to carbendazim and slightly lower than cyazofamid. Untargeted metabolomic analysis revealed pronounced perturbations in tricarboxylic acid (TCA) cycle flux and amino acid biosynthesis, highlighting mitochondrial energy metabolism, with SDH\u2010associated processes emerging as a sensitive metabolic node affected by\n 8c<\/jats:bold>\n treatment. This finding was supported by enzymatic assays showing reduced SDH activity. However, the metabolic profile indicates a systemic bioenergetic collapse rather than simple enzyme inhibition. This suggests\n 8c<\/jats:bold>\n likely disrupts mitochondrial membrane integrity, leading to an oxidative cascade marked by surging malondialdehyde (MDA) levels and compromised antioxidant defenses. Crucially, acute toxicity assays further indicated a favorable safety profile toward representative non\u2010target organisms, including silkworms, zebrafish, and earthworms.\n <\/jats:p>\n <\/jats:sec>\n \n CONCLUSION<\/jats:title>\n \n Collectively, these results identify compound\n 8c<\/jats:bold>\n as a promising anti\u2010oomycete lead that combines high efficacy, multi\u2010level metabolic disruption, and encouraging safety characteristics for late blight management. \u00a9 2026 Society of Chemical Industry.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/ps.70950","type":"journal-article","created":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T04:26:59Z","timestamp":1779942419000},"page":"9040-9054","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Structure guided development of phenoxyethanol based\n \n N<\/i>\n <\/scp>\n \u2010aryloxyethyl heterocycles for the control of\n \n Phytophthora infestans<\/i>\n <\/scp>"],"prefix":"10.1002","volume":"82","author":[{"given":"Lan\u2010Tu","family":"Xiong","sequence":"first","affiliation":[{"name":"Key Laboratory of Advanced Materials for Facility Agriculture, Ministry of Agriculture, College of Materials and Chemical Engineering South China Agricultural University Guangzhou P. R. China"},{"name":"State Key Laboratory of Green Pesticide, Integrative Microbiology Research Centre, Guangdong Provincial Key Laboratory of Microbial Signals and Disease Control, College of Plant Protection South China Agricultural University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijuan","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Advanced Materials for Facility Agriculture, Ministry of Agriculture, College of Materials and Chemical Engineering South China Agricultural University Guangzhou P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuefen","family":"Zheng","sequence":"additional","affiliation":[{"name":"Key Laboratory of Advanced Materials for Facility Agriculture, Ministry of Agriculture, College of Materials and Chemical Engineering South China Agricultural University Guangzhou P. R. 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