{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T00:14:44Z","timestamp":1789172084952,"version":"build-2803163510"},"reference-count":54,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,6,21]],"date-time":"2026-06-21T00:00:00Z","timestamp":1782000000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,21]],"date-time":"2026-06-21T00:00:00Z","timestamp":1782000000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pest Management Science"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>Global crop losses caused by plant viruses, particularly tobacco mosaic virus (TMV), amount to billions of dollars per year, necessitating the urgent development of potent and environmentally friendly antiviral agents.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Twelve natural products were identified from\n                      <jats:italic>P. strobilacea<\/jats:italic>\n                      seeds. Among them, (\u2212)\u2010Epicatechin 3\u2010gallate (\n                      <jats:bold>1<\/jats:bold>\n                      ) showed higher anti\u2010TMV activity than ningnanmycin at 125\u2013500\u2009\u03bcg\u2009mL\n                      <jats:sup>\u22121<\/jats:sup>\n                      , with inhibition rates of 49.36\u201380.27%, 39.34\u201370.28%, 33.48\u201363.13%, and 32.18\u201365.17% in inactivation, protective, curative, and resistance\u2010inducing assays, respectively. Compound\n                      <jats:bold>1<\/jats:bold>\n                      disrupted TMV particle integrity and reduced\n                      <jats:italic>TMV\u2010CP<\/jats:italic>\n                      gene expression. Molecular docking further suggested a potential interaction between\n                      <jats:bold>1<\/jats:bold>\n                      and TMV\u2010CP, with a predicted binding affinity of \u22127.5\u2009kcal\u2009mol\n                      <jats:sup>\u22121<\/jats:sup>\n                      through hydrogen\u2010bonding interactions. In addition,\n                      <jats:bold>1<\/jats:bold>\n                      enhanced salicylic acid accumulation, increased H\u2082O\u2082 levels, activated defense enzymes including superoxide dismutase, peroxidase, and catalase, and upregulated defense\u2010related genes including\n                      <jats:italic>NPR1, PR1, PR2, PR5,<\/jats:italic>\n                      and\n                      <jats:italic>PAL.<\/jats:italic>\n                      Lesion phenotype and relative electrical conductivity assays suggested that\n                      <jats:bold>1<\/jats:bold>\n                      induced a mild local HR\u2010like response with limited membrane damage.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>\n                      These results suggest that (\u2010)\u2010Epicatechin 3\u2010gallate (\n                      <jats:bold>1<\/jats:bold>\n                      ) is a promising lead compound for further development as both a direct\u2010acting antiviral agent and a plant immune elicitor against TMV. \u00a9 2026 Society of Chemical Industry.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ps.71052","type":"journal-article","created":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T04:50:15Z","timestamp":1782103815000},"page":"10147-10159","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Identification of (\u2010)\u2010Epicatechin 3\u2010gallate from seeds of\n                    <scp>\n                      <i>Platycarya strobilacea<\/i>\n                    <\/scp>\n                    with dual\u2010functions of direct antivirus and plant immune elicitation against\n                    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