{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T00:15:36Z","timestamp":1789172136806,"version":"build-2803163510"},"reference-count":47,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T00:00:00Z","timestamp":1782691200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T00:00:00Z","timestamp":1782691200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pest Management Science"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>\n                      Peanut southern blight, caused by\n                      <jats:italic>Sclerotium rolfsii<\/jats:italic>\n                      , severely reduces yield and quality. The overuse of chemical fungicides accelerates resistance development and raises environmental concerns, highlighting the necessity for eco\u2010friendly alternatives. Hypogin is an endogenous peanut peptide with broad\u2010spectrum antifungal activity. This study aims to identify the active centers of hypogin and evaluate the antifungal activity and preliminary mechanisms of its derived peptides.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Seven hypogin\u2010derived peptides (series I) and two cinnamic acid conjugates (series II) were synthesized. Among these, II\u20101 (cinnamic\u2010KSPY\u2010NH\n                      <jats:sub>2<\/jats:sub>\n                      ) demonstrated the highest\n                      <jats:italic>in vitro<\/jats:italic>\n                      activity against\n                      <jats:italic>S<\/jats:italic>\n                      .\n                      <jats:italic>rolfsii,<\/jats:italic>\n                      with a half\u2010maximal effective concentration value of 257.93 mg\/L.\n                      <jats:italic>In vivo<\/jats:italic>\n                      studies revealed that II\u20101 provided superior curative efficacy (66.47%) against peanut southern blight, surpassing the commercial fungicide polyoxin (57.33%), and also promoted root growth in peanuts. Both I\u20107 and II\u20101 exhibited low cytotoxicity toward human LO2 liver cells, with inhibition rates of 5.05% and 17.44%, respectively, at a concentration of 400\u2009mg\/L. Preliminary mechanistic investigations indicated that I\u20107 specifically targets the Vps34 signaling pathway in\n                      <jats:italic>S<\/jats:italic>\n                      .\n                      <jats:italic>rolfsii<\/jats:italic>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Hypogin\u2010derived peptide II\u20101 exhibits significant antifungal activity and low toxicity, making it a promising candidate for a green fungicide in the management of peanut southern blight. \u00a9 2026 Society of Chemical Industry.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ps.71059","type":"journal-article","created":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T03:51:41Z","timestamp":1782791501000},"page":"10231-10240","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Hypogin\u2010derived N\u2010cinnamoylated peptide as a promising green fungicide against peanut southern blight caused by\n                    <scp>\n                      <i>S<\/i>\n                    <\/scp>\n                    <i>clerotium rolfsii<\/i>"],"prefix":"10.1002","volume":"82","author":[{"given":"Guangyao","family":"Li","sequence":"first","affiliation":[{"name":"College of Plant Protection, Henan Agricultural University  Zhengzhou China"},{"name":"State Key Laboratory of Agricultural and Forestry Biosecurity, College of Plant Protection, Nanjing Agricultural University  Nanjing 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